Analysis of Aneurysmal bone cysts
Analysis of Aneurysmal bone cysts G2D Home
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REASONS FOR ASSOCIATION OVERVIEW OF CANDIDATES BEST 10 CANDIDATES ALL 26 CANDIDATES

CHROMOSOMAL REGION
Disease mapped: Aneurysmal bone cysts
Method: Md
Chromosome: 16
Genomic position start-stop: 63850000-73850000
length: 10000001
Band: 16q22
 LINKS

EntrezGene: [114293]

MEDLINE:

OMIM: [606179] XplorMed

REASONS FOR ASSOCIATION

MEDLINE QUERY
A set of 915 papers related to this disease was derived from MEDLINE using the query:
Aneurysmal [tw] AND bone [tw] AND cysts [tw]

MESH-C TERMS
The MeSH-C terms associated to the derived papers were collected.

Here you can see the terms ordered by the number of papers where they were found (number in brackets).

Bone Cysts [609]
Bone Cysts, Aneurysmal [271]
Bone Neoplasms [164]
Spinal Diseases [87]
Mandibular Diseases [63]
Giant Cell Tumors [61]
Spinal Neoplasms [59]
Recurrence [59]
Osteosarcoma [55]
Aneurysm [54]
We show here only the 10 most frequent. You can also see the complete list of 290 MeSH-C terms.

Each name is linked to the corresponding term description by the NLM. The number in brackets is linked to the list of papers that contained the term. The points to the related MeSH-D terms.

 GO terms
We computed the GO terms associated to the MeSH-C terms selected for this disease.

Here you can see those with higher score of association.

0.000214 luteinizing hormone-releasing factor activity (function)
0.000097 DNA-directed RNA polymerase II activity (function)
0.000071 hormone activity (function)
0.000059 drug resistance (process)
0.000049 DNA-directed RNA polymerase II, core complex (component)
0.000031 cytosolic small ribosomal subunit (sensu Eukaryota) (component)
0.000024 26S proteasome (component)
0.000018 ubiquitin-dependent protein catabolism (process)
0.000014 structural constituent of ribosome (function)

Each name is linked to the corresponding term description by GO. The number indicates the strength of association to Aneurysmal bone cysts. The points to the related MeSH-D terms.
Follow the green arrows to navigate MeSH-C / MeSH-D / GO-terms relationship derived from our analysis of the whole MEDLINE database, and used to relate the phenotype of this disease to terms of gene functionality.

OVERVIEW OF CANDIDATES IN THE REGION

The graph represents the BLASTX hits found in the region and the genes predicted or known in the region.

Legend:
BLASTX hits RefSeq genes Ensembl genes
                                                         
> 1e-10 > 1e-20 > 1e-50 > 1e-80 > 1e-100 > 0
                       
               

Graph with GO scoring vs genomic position [PostScript graphic]

BEST SCORING 10 CANDIDATES
Here we show only the best scoring ten candidates but there are more. You can see the best scoring 100 candidates.

What is in a candidate?

CANDIDATE 1
DNA (Note) PROTEIN: [NP_003860] [NP_932327]
R-score = 0.006041; GO-score = 0.000071
63850000 bp Chromosome 16 73850000 bp
   
   
1 aa NP_003226 2768 aa

Similarity found to protein:
[7038|NP_003226] | Homo sapiens | thyroglobulin | length=2768 aa
GO annotation:
0.000071 hormone activity (function)
0.000000 extracellular region (component)
0.000000 thyroid hormone generation (process)
0.000000 signal transduction (process)
0.000000 hormone biosynthesis (process)
BLASTX hits:
E-value 5e-12 prot=2318..2425 DNA=65531681..65532079 fr=2768 per=49/135 [EST]
CANDIDATE 2
DNA (Note)
R-score = 0.006501; GO-score = 0.000071
63850000 bp Chromosome 16 73850000 bp
   
   
1 aa NP_035735 693 aa

Similarity found to protein:
[21917|NP_035735] | Mus musculus | thymopoietin | length=693 aa
GO annotation:
0.000000 DNA binding (function)
0.000071 hormone activity (function)
0.000000 protein binding (function)
0.000000 nucleus (component)
0.000000 nuclear envelope (component)
0.000000 chromosome (component)
0.000000 integral to membrane (component)
0.000000 regulation of transcription (process)
BLASTX hits:
E-value 1e-19 prot=51..190 DNA=73258906..73259304 fr=693 per=100/141 [EST]
CANDIDATE 3
DNA (Note)
R-score = 0.008975; GO-score = 0.000071
63850000 bp Chromosome 16 73850000 bp
   
   
1 aa NP_037019 452 aa

Similarity found to protein:
[25359|NP_037019] | Rattus norvegicus | thymopoietin | length=452 aa
GO annotation:
0.000000 DNA binding (function)
0.000071 hormone activity (function)
0.000000 protein binding (function)
0.000000 lamin binding (function)
0.000000 nucleus (component)
0.000000 nuclear envelope (component)
0.000000 chromosome (component)
0.000000 integral to membrane (component)
0.000000 regulation of transcription (process)
BLASTX hits:
E-value 2e-78 prot=191..328 DNA=73259304..73259720 fr=452 per=108/139 [EST]
E-value 9e-35 prot=317..447 DNA=73259684..73260085 fr=452 per=88/135 [EST]
E-value 2e-78 prot=51..197 DNA=73258906..73259325 fr=452 per=101/148 [EST]
CANDIDATE 4
DNA (Note) PROTEIN: [NP_710155]

This candidate may be overlapping with a pseudogene (Note)
R-score = 0.010241; GO-score = 0.000049
63850000 bp Chromosome 16 73850000 bp
    
   
1 aa NP_068799 794 aa

Similarity found to protein:
[7707|NP_068799] | Homo sapiens | zinc finger protein 148 (pHZ-52) | length=794 aa
GO annotation:

0.000000 negative regulation of transcription from RNA polymerase II promoter (process)
0.000000 DNA binding (function)
0.000000 specific RNA polymerase II transcription factor activity (function)
0.000000 nucleus (component)
0.000049 DNA-directed RNA polymerase II, core complex (component)
0.000000 transcription (process)
0.000000 regulation of transcription, DNA-dependent (process)
0.000000 cellular defense response (process)
0.000000 zinc ion binding (function)
0.000000 transcriptional activator activity (function)
0.000000 metal ion binding (function)
BLASTX hits:
E-value 3e-22 prot=169..280 DNA=67155759..67156094 fr=794 per=49/112 [EST] [P]
E-value 5e-21 prot=169..275 DNA=67155030..67155350 fr=794 per=49/107 [EST] [P]
E-value 5e-20 prot=169..276 DNA=67155675..67155998 fr=794 per=44/108 [EST] [P]
E-value 2e-19 prot=169..276 DNA=67155114..67155437 fr=794 per=45/108 [EST] [P]
E-value 7e-18 prot=169..274 DNA=67154946..67155263 fr=794 per=43/106 [EST] [P]
E-value 1e-16 prot=193..288 DNA=67155663..67155950 fr=794 per=39/96 [EST] [P]
E-value 4e-15 prot=192..288 DNA=67154931..67155221 fr=794 per=37/97 [EST] [P]
E-value 4e-14 prot=169..256 DNA=67155198..67155461 fr=794 per=39/88 [EST] [P]
E-value 5e-13 prot=169..253 DNA=67155843..67156097 fr=794 per=35/85 [EST] [P]
E-value 1e-20 prot=169..276 DNA=73761306..73761629 fr=794 per=47/108 [EST] [P]
E-value 3e-19 prot=172..289 DNA=73761063..73761416 fr=794 per=46/118 [EST] [P]
E-value 3e-19 prot=169..276 DNA=73761390..73761713 fr=794 per=47/108 [EST] [P]
E-value 2e-18 prot=169..276 DNA=73761138..73761461 fr=794 per=40/108 [EST] [P]
E-value 6e-17 prot=169..275 DNA=73761222..73761542 fr=794 per=40/107 [EST] [P]
E-value 5e-16 prot=169..254 DNA=73761474..73761731 fr=794 per=39/86 [EST] [P]
E-value 3e-13 prot=188..288 DNA=73761027..73761329 fr=794 per=37/101 [EST] [P]
CANDIDATE 5
DNA (Note)

This candidate may be overlapping with a pseudogene (Note)
R-score = 0.011794; GO-score = 0.000031
63850000 bp Chromosome 16 73850000 bp
     
 
1 aa NP_001005 165 aa

Similarity found to protein:
[6204|NP_001005] | Homo sapiens | ribosomal protein S10 | length=165 aa
GO annotation:

0.000000 RNA binding (function)
0.000014 structural constituent of ribosome (function)
0.000031 cytosolic small ribosomal subunit (sensu Eukaryota) (component)
0.000000 protein biosynthesis (process)
0.000000 ribonucleoprotein complex (component)
BLASTX hits:
E-value 1e-56 prot=1..79 DNA=68671029..68670790 fr=165 per=69/80 [EST] [P]
E-value 1e-56 prot=76..165 DNA=68670803..68670537 fr=165 per=54/90 [EST] [P]
E-value 1e-56 prot=1..79 DNA=73143651..73143890 fr=165 per=68/80 [EST] [P]
E-value 1e-56 prot=76..165 DNA=73143877..73144143 fr=165 per=55/90 [EST] [P]
CANDIDATE 6
DNA (Note)
R-score = 0.011852; GO-score = 0.000031
63850000 bp Chromosome 16 73850000 bp
   
  
1 aa NP_001021 84 aa

Similarity found to protein:
[6232|NP_001021] | Homo sapiens | ribosomal protein S27 | length=84 aa
GO annotation:
0.000000 RNA binding (function)
0.000014 structural constituent of ribosome (function)
0.000000 ribosome (component)
0.000031 cytosolic small ribosomal subunit (sensu Eukaryota) (component)
0.000000 protein biosynthesis (process)
0.000000 signal transduction (process)
0.000000 zinc ion binding (function)
0.000000 cell proliferation (process)
0.000000 metal ion binding (function)
BLASTX hits:
E-value 1e-17 prot=16..84 DNA=69036279..69036079 fr=84 per=47/69 [EST]
E-value 1e-17 prot=3..21 DNA=69036317..69036261 fr=84 per=14/19 [EST]
CANDIDATE 7
DNA (Note) PROTEIN: [NP_079262]
R-score = 0.011967; GO-score = 0.000031
63850000 bp Chromosome 16 73850000 bp
   
  
1 aa NP_002943 293 aa

Similarity found to protein:
[6187|NP_002943] | Homo sapiens | ribosomal protein S2 | length=293 aa
GO annotation:
0.000000 RNA binding (function)
0.000014 structural constituent of ribosome (function)
0.000000 intracellular (component)
0.000000 ribosome (component)
0.000031 cytosolic small ribosomal subunit (sensu Eukaryota) (component)
0.000000 protein biosynthesis (process)
0.000000 small ribosomal subunit (component)
BLASTX hits:
E-value 5e-94 prot=14..270 DNA=67625097..67625864 fr=293 per=171/257 [EST]
E-value 5e-94 prot=268..292 DNA=67625852..67625926 fr=293 per=19/25 [EST]
CANDIDATE 8
DNA (Note)
R-score = 0.012542; GO-score = 0.000031
63850000 bp Chromosome 16 73850000 bp
  
  
1 aa NP_033120 263 aa

Similarity found to protein:
[20102|NP_033120] | Mus musculus | ribosomal protein S4, X-linked | length=263 aa
GO annotation:
0.000000 regulation of progression through cell cycle (process)
0.000000 RNA binding (function)
0.000014 structural constituent of ribosome (function)
0.000000 intracellular (component)
0.000000 cytosolic ribosome (sensu Eukaryota) (component)
0.000000 ribosome (component)
0.000031 cytosolic small ribosomal subunit (sensu Eukaryota) (component)
0.000000 protein biosynthesis (process)
0.000000 ribosome biogenesis (process)
0.000000 development (process)
0.000000 cell proliferation (process)
0.000000 ribonucleoprotein complex (component)
BLASTX hits:
E-value 1e-101 prot=106..260 DNA=73784336..73783875 fr=263 per=112/155 [EST]
E-value 1e-101 prot=1..106 DNA=73784647..73784333 fr=263 per=85/106 [EST]
CANDIDATE 9
DNA (Note)
R-score = 0.012657; GO-score = 0.000031
63850000 bp Chromosome 16 73850000 bp
   
 
1 aa NP_002286 295 aa

Similarity found to protein:
[3921|NP_002286] | Homo sapiens | laminin receptor 1 | length=295 aa
GO annotation:
0.000014 structural constituent of ribosome (function)
0.000000 laminin receptor activity (function)
0.000031 cytosolic small ribosomal subunit (sensu Eukaryota) (component)
0.000000 protein biosynthesis (process)
0.000000 regulation of translation (process)
0.000000 cell adhesion (process)
0.000000 cell surface receptor linked signal transduction (process)
0.000000 integrin complex (component)
0.000000 small ribosomal subunit (component)
BLASTX hits:
E-value 1e-139 prot=1..295 DNA=72532925..72532041 fr=295 per=270/295 [EST]
CANDIDATE 10
DNA (Note)
R-score = 0.013003; GO-score = 0.000031
63850000 bp Chromosome 16 73850000 bp
  
 
1 aa NP_524053 261 aa

Similarity found to protein:
[39484|NP_524053] | Drosophila melanogaster | Ribosomal protein S4 CG11276-PB | length=261 aa
GO annotation:
0.000000 nucleic acid binding (function)
0.000000 mRNA binding (function)
0.000014 structural constituent of ribosome (function)
0.000000 ribosome (component)
0.000031 cytosolic small ribosomal subunit (sensu Eukaryota) (component)
0.000000 protein biosynthesis (process)
BLASTX hits:
E-value 4e-81 prot=106..259 DNA=73784336..73783878 fr=261 per=84/154 [EST]
E-value 4e-81 prot=1..104 DNA=73784647..73784339 fr=261 per=73/104 [EST]