Analysis of Aneurysm, intracranial berry
Analysis of Aneurysm, intracranial berry G2D Home
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REASONS FOR ASSOCIATION OVERVIEW OF CANDIDATES CANDIDATES

CHROMOSOMAL REGION
Disease mapped: Aneurysm, intracranial berry
Method: Md
Chromosome: 7
Genomic position start-stop: 61200000-77200000
length: 16000001
Band: 7q11.2
 LINKS

EntrezGene: [116833]

MEDLINE:

OMIM: [105800] XplorMed

REASONS FOR ASSOCIATION

MEDLINE QUERY
A set of 143 papers related to this disease was derived from MEDLINE using the query:
Aneurysm [tw] AND intracranial [tw] AND berry [tw]

MESH-C TERMS
The MeSH-C terms associated to the derived papers were collected.

Here you can see the terms ordered by the number of papers where they were found (number in brackets).

Intracranial Aneurysm [133]
Subarachnoid Hemorrhage [33]
Rupture, Spontaneous [28]
Cerebral Hemorrhage [16]
Aneurysm, Ruptured [15]
Carotid Artery Diseases [12]
Postoperative Complications [8]
Brain Neoplasms [8]
Hypertension [8]
Aneurysm [7]
We show here only the 10 most frequent. You can also see the complete list of 118 MeSH-C terms.

Each name is linked to the corresponding term description by the NLM. The number in brackets is linked to the list of papers that contained the term. The points to the related MeSH-D terms.

 GO terms
We computed the GO terms associated to the MeSH-C terms selected for this disease.

Here you can see those with higher score of association.

0.000225 cathepsin D activity (function)
0.000225 renin activity (function)
0.000102 blood pressure regulation (process)
0.000043 serine-type endopeptidase activity (function)
0.000037 endopeptidase inhibitor activity (function)
0.000017 proteolysis (process)
0.000016 lysosome (component)

Each name is linked to the corresponding term description by GO. The number indicates the strength of association to Aneurysm, intracranial berry. The points to the related MeSH-D terms.
Follow the green arrows to navigate MeSH-C / MeSH-D / GO-terms relationship derived from our analysis of the whole MEDLINE database, and used to relate the phenotype of this disease to terms of gene functionality.

OVERVIEW OF CANDIDATES IN THE REGION

The graph represents the BLASTX hits found in the region and the genes predicted or known in the region.

Legend:
BLASTX hits RefSeq genes Ensembl genes
                                           
> 1e-10 > 1e-20 > 1e-50 > 1e-80 > 1e-100 > 0
                                       
                                       

Graph with GO scoring vs genomic position [PostScript graphic]

CANDIDATES
CANDIDATE 1
DNA (Note) PROTEIN: [NP_006673]
R-score = 0.000460; GO-score = 0.000102
61200000 bp Chromosome 7 77200000 bp
   
   
1 aa NP_068656 453 aa

Similarity found to protein:
[2266|NP_068656] | Homo sapiens | fibrinogen, gamma chain isoform gamma-B precursor | length=453 aa
GO annotation:
0.000000 calcium ion binding (function)
0.000000 fibrinogen complex (component)
0.000000 signal transduction (process)
0.000102 blood pressure regulation (process)
0.000000 positive regulation of cell proliferation (process)
0.000000 platelet activation (process)
0.000000 protein polymerization (process)
BLASTX hits:
E-value 9e-35 prot=177..398 DNA=76470937..76470338 fr=453 per=93/223 [EST]
CANDIDATE 2
DNA (Note) PROTEIN: [NP_003499]
R-score = 0.001784; GO-score = 0.000102
61200000 bp Chromosome 7 77200000 bp
   
   
1 aa NP_006578 1042 aa

Similarity found to protein:
[10699|NP_006578] | Homo sapiens | corin | length=1042 aa
GO annotation:
0.000043 serine-type endopeptidase activity (function)
0.000000 scavenger receptor activity (function)
0.000000 plasma membrane (component)
0.000000 integral to plasma membrane (component)
0.000017 proteolysis (process)
0.000000 lipid metabolism (process)
0.000102 blood pressure regulation (process)
0.000000 peptidase activity (function)
0.000000 morphogenesis (process)
BLASTX hits:
E-value 8e-14 prot=444..575 DNA=72293074..72293460 fr=1042 per=40/132 [EST]
CANDIDATE 3
DNA (Note) PROTEIN: [NP_009086] [NP_542782]
R-score = 0.009033; GO-score = 0.000043
61200000 bp Chromosome 7 77200000 bp
   
   
1 aa NP_032965 761 aa

Similarity found to protein:
[19142|NP_032965] | Mus musculus | protease, serine, 12 neurotrypsin (motopsin) | length=761 aa
GO annotation:
0.000043 serine-type endopeptidase activity (function)
0.000000 protein-lysine 6-oxidase activity (function)
0.000000 scavenger receptor activity (function)
0.000000 copper ion binding (function)
0.000000 extracellular space (component)
0.000017 proteolysis (process)
0.000000 peptidase activity (function)
0.000000 membrane (component)
0.000000 hydrolase activity (function)
BLASTX hits:
E-value 1e-23 prot=166..265 DNA=75671790..75671491 fr=761 per=53/100 [EST]
E-value 2e-21 prot=166..263 DNA=75664339..75664046 fr=761 per=52/98 [EST]
E-value 7e-21 prot=386..485 DNA=75671790..75671491 fr=761 per=52/100 [EST]
E-value 9e-21 prot=180..270 DNA=75667635..75667363 fr=761 per=47/91 [EST]
E-value 6e-20 prot=386..483 DNA=75664339..75664046 fr=761 per=50/98 [EST]
E-value 9e-16 prot=400..485 DNA=75667635..75667378 fr=761 per=43/87 [EST]
E-value 8e-15 prot=166..265 DNA=75674558..75674259 fr=761 per=50/100 [EST]
E-value 1e-14 prot=270..371 DNA=75671799..75671491 fr=761 per=42/103 [EST]
E-value 2e-13 prot=386..486 DNA=75674558..75674256 fr=761 per=47/101 [EST]
E-value 1e-12 prot=271..369 DNA=75664345..75664046 fr=761 per=40/100 [EST]
E-value 8e-12 prot=287..376 DNA=75667635..75667363 fr=761 per=36/91 [EST]
CANDIDATE 4
DNA (Note) PROTEIN: [NP_001013768] [NP_006515] [NP_009070] [NP_056936] [NP_057304] [NP_066971] [NP_078774] [NP_689839] [NP_699194] [NP_848653]

This candidate may be overlapping with a pseudogene (Note)
R-score = 0.025890; GO-score = 0.000017
61200000 bp Chromosome 7 77200000 bp
           
   
1 aa NP_477304 845 aa

Similarity found to protein:
[38718|NP_477304] | Drosophila melanogaster | D19A-P1 CG10269-PA | length=845 aa
GO annotation:

0.000000 nucleic acid binding (function)
0.000000 nucleus (component)
0.000000 nucleobase, nucleoside, nucleotide and nucleic acid metabolism (process)
0.000000 regulation of transcription from RNA polymerase II promoter (process)
0.000000 transcription from RNA polymerase II promoter (process)
0.000017 proteolysis (process)
0.000000 metallopeptidase activity (function)
0.000000 zinc ion binding (function)
0.000000 cell proliferation (process)
0.000000 transcription regulator activity (function)
BLASTX hits:
E-value 6e-12 prot=442..539 DNA=61992404..61992114 fr=845 per=34/98 [EST] [P]
E-value 6e-12 prot=375..413 DNA=61992613..61992500 fr=845 per=18/39 [EST] [P]
E-value 1e-32 prot=335..732 DNA=62360074..62361207 fr=845 per=118/417 [EST] [P]
E-value 1e-29 prot=280..539 DNA=62360458..62361192 fr=845 per=85/260 [EST] [P]
E-value 1e-29 prot=280..539 DNA=62360206..62360940 fr=845 per=86/261 [EST] [P]
E-value 2e-28 prot=280..539 DNA=62360374..62361108 fr=845 per=84/260 [EST] [P]
E-value 2e-28 prot=276..539 DNA=62982170..62983000 fr=845 per=91/285 [EST] [P]
E-value 9e-26 prot=256..525 DNA=62360431..62361234 fr=845 per=86/283 [EST] [P]
E-value 3e-23 prot=335..557 DNA=62197189..62196521 fr=845 per=75/232 [EST] [P]
E-value 8e-22 prot=295..539 DNA=62919898..62920581 fr=845 per=78/245 [EST] [P]
E-value 2e-21 prot=280..524 DNA=62982350..62983039 fr=845 per=76/245 [EST] [P]
E-value 6e-22 prot=305..496 DNA=62196563..62196033 fr=845 per=66/192 [EST] [P]
E-value 2e-26 prot=373..539 DNA=62196566..62196072 fr=845 per=57/167 [EST] [P]
E-value 2e-19 prot=338..525 DNA=62196560..62196030 fr=845 per=64/188 [EST] [P]
E-value 5e-14 prot=407..539 DNA=62982020..62982412 fr=845 per=47/134 [EST] [P]
E-value 2e-13 prot=379..526 DNA=62983359..62983796 fr=845 per=53/149 [EST] [P]
E-value 3e-13 prot=375..539 DNA=62919763..62920251 fr=845 per=48/165 [EST] [P]
E-value 6e-12 prot=373..512 DNA=62983425..62983838 fr=845 per=46/140 [EST] [P]
E-value 6e-12 prot=260..477 DNA=62982470..62983069 fr=845 per=68/218 [EST] [P]
E-value 1e-14 prot=283..438 DNA=62196461..62196036 fr=845 per=52/156 [EST] [P]
E-value 2e-11 prot=284..539 DNA=62780864..62781595 fr=845 per=74/259 [EST] [P]
E-value 2e-14 prot=345..438 DNA=62983030..62983287 fr=845 per=36/94 [EST] [P]
E-value 2e-14 prot=454..539 DNA=62983329..62983583 fr=845 per=28/86 [EST] [P]
E-value 2e-26 prot=280..363 DNA=62196805..62196575 fr=845 per=27/84 [EST] [P]
E-value 1e-14 prot=450..492 DNA=62196009..62195884 fr=845 per=14/43 [EST] [P]
E-value 6e-22 prot=506..539 DNA=62196012..62195911 fr=845 per=10/34 [EST] [P]
E-value 3e-43 prot=280..776 DNA=63611653..63613068 fr=845 per=141/510 [EST] [P]
E-value 4e-40 prot=263..732 DNA=63883640..63882264 fr=845 per=142/491 [EST] [P]
E-value 6e-38 prot=265..732 DNA=63611788..63613074 fr=845 per=138/478 [EST] [P]
E-value 2e-34 prot=306..732 DNA=63611059..63612234 fr=845 per=121/433 [EST] [P]
E-value 4e-34 prot=296..738 DNA=63832443..63833666 fr=845 per=127/452 [EST] [P]
E-value 9e-34 prot=280..737 DNA=63736444..63737700 fr=845 per=127/469 [EST] [P]
E-value 2e-33 prot=280..732 DNA=63736360..63737613 fr=845 per=127/469 [EST] [P]
E-value 7e-32 prot=280..537 DNA=63882257..63881529 fr=845 per=90/258 [EST] [P]
E-value 3e-31 prot=373..732 DNA=63736264..63737277 fr=845 per=104/363 [EST] [P]
E-value 3e-31 prot=280..539 DNA=63832563..63833297 fr=845 per=89/260 [EST] [P]
E-value 4e-30 prot=280..541 DNA=63736612..63737352 fr=845 per=90/262 [EST] [P]
E-value 6e-30 prot=263..539 DNA=63882548..63881775 fr=845 per=92/278 [EST] [P]
E-value 1e-29 prot=369..732 DNA=63611041..63612066 fr=845 per=98/368 [EST] [P]
E-value 5e-29 prot=280..539 DNA=63882425..63881691 fr=845 per=90/260 [EST] [P]
E-value 5e-29 prot=274..537 DNA=63252981..63253727 fr=845 per=91/264 [EST] [P]
E-value 9e-29 prot=280..539 DNA=63426397..63425663 fr=845 per=88/260 [EST] [P]
E-value 8e-28 prot=263..556 DNA=63882380..63881556 fr=845 per=93/294 [EST] [P]
E-value 4e-27 prot=280..539 DNA=63426481..63425747 fr=845 per=85/264 [EST] [P]
E-value 1e-26 prot=343..539 DNA=63124226..63124789 fr=845 per=70/197 [EST] [P]
E-value 1e-26 prot=280..539 DNA=63252831..63253565 fr=845 per=83/262 [EST] [P]
E-value 2e-26 prot=308..539 DNA=63252825..63253481 fr=845 per=78/232 [EST] [P]
E-value 2e-26 prot=280..544 DNA=63252906..63253664 fr=845 per=86/268 [EST] [P]
E-value 2e-26 prot=279..539 DNA=63832812..63833549 fr=845 per=84/261 [EST] [P]
E-value 1e-25 prot=280..539 DNA=63611401..63612219 fr=845 per=88/288 [EST] [P]
E-value 2e-25 prot=269..526 DNA=63170748..63171491 fr=845 per=83/265 [EST] [P]
E-value 4e-25 prot=375..539 DNA=63170796..63171284 fr=845 per=63/165 [EST] [P]
E-value 4e-25 prot=343..539 DNA=63170805..63171368 fr=845 per=69/197 [EST] [P]
E-value 8e-25 prot=276..543 DNA=63426745..63425987 fr=845 per=84/269 [EST] [P]
E-value 2e-24 prot=280..541 DNA=63426565..63425825 fr=845 per=85/262 [EST] [P]
E-value 5e-24 prot=280..526 DNA=63832899..63833594 fr=845 per=79/247 [EST] [P]
E-value 3e-23 prot=280..518 DNA=63124223..63124888 fr=845 per=78/239 [EST] [P]
E-value 4e-23 prot=228..539 DNA=63612118..63613143 fr=845 per=101/361 [EST] [P]
E-value 6e-23 prot=295..541 DNA=63124184..63124879 fr=845 per=79/247 [EST] [P]
E-value 6e-22 prot=306..539 DNA=63736186..63736842 fr=845 per=73/236 [EST] [P]
E-value 6e-22 prot=276..539 DNA=63426829..63426083 fr=845 per=84/264 [EST] [P]
E-value 8e-22 prot=263..514 DNA=63832944..63833642 fr=845 per=83/252 [EST] [P]
E-value 1e-21 prot=263..511 DNA=63170847..63171530 fr=845 per=75/249 [EST] [P]
E-value 3e-21 prot=390..539 DNA=63170757..63171200 fr=845 per=58/150 [EST] [P]
E-value 5e-21 prot=280..539 DNA=63882005..63881277 fr=845 per=82/260 [EST] [P]
E-value 9e-21 prot=280..559 DNA=63736948..63737736 fr=845 per=83/281 [EST] [P]
E-value 9e-18 prot=300..539 DNA=63123938..63124621 fr=845 per=68/242 [EST] [P]
E-value 8e-17 prot=280..494 DNA=63833067..63833672 fr=845 per=67/217 [EST] [P]
E-value 3e-14 prot=375..542 DNA=63883859..63883356 fr=845 per=53/170 [EST] [P]
E-value 5e-14 prot=375..539 DNA=63170628..63171116 fr=845 per=50/165 [EST] [P]
E-value 7e-13 prot=280..539 DNA=63612661..63613473 fr=845 per=74/285 [EST] [P]
E-value 1e-12 prot=280..468 DNA=63426145..63425621 fr=845 per=61/189 [EST] [P]
E-value 3e-12 prot=390..551 DNA=63374706..63375170 fr=845 per=52/162 [EST] [P]
E-value 3e-15 prot=411..544 DNA=63374682..63375080 fr=845 per=41/134 [EST] [P]
E-value 5e-11 prot=280..462 DNA=63253251..63253757 fr=845 per=58/187 [EST] [P]
E-value 3e-11 prot=437..526 DNA=63374257..63374523 fr=845 per=30/90 [EST] [P]
E-value 3e-11 prot=345..436 DNA=63374006..63374257 fr=845 per=32/92 [EST] [P]
E-value 3e-15 prot=283..401 DNA=63374341..63374658 fr=845 per=31/119 [EST] [P]
E-value 8e-17 prot=487..541 DNA=63833770..63833934 fr=845 per=17/55 [EST] [P]
E-value 3e-33 prot=280..541 DNA=64307869..64308609 fr=845 per=91/262 [EST] [P]
E-value 4e-31 prot=280..539 DNA=64307785..64308519 fr=845 per=88/260 [EST] [P]
E-value 4e-30 prot=373..732 DNA=64307689..64308786 fr=845 per=103/372 [EST] [P]
E-value 3e-27 prot=424..732 DNA=64307671..64308534 fr=845 per=90/311 [EST] [P]
E-value 5e-27 prot=280..539 DNA=64307953..64308687 fr=845 per=86/260 [EST] [P]
E-value 7e-26 prot=263..535 DNA=64308082..64308843 fr=845 per=83/273 [EST] [P]
E-value 1e-21 prot=280..534 DNA=64308205..64308921 fr=845 per=75/255 [EST] [P]
CANDIDATE 5
DNA (Note)
R-score = 0.048444; GO-score = 0.000017
61200000 bp Chromosome 7 77200000 bp
   
  
1 aa NP_611796 171 aa

Similarity found to protein:
[37713|NP_611796] | Drosophila melanogaster | CG12227-PA | length=171 aa
GO annotation:
0.000000 regulation of progression through cell cycle (process)
0.000000 nuclear ubiquitin ligase complex (component)
0.000000 ubiquitin-protein ligase activity (function)
0.000017 proteolysis (process)
0.000000 chromosome segregation (process)
0.000000 mitosis (process)
0.000000 centromeric DNA binding (function)
BLASTX hits:
E-value 5e-33 prot=1..161 DNA=65333031..65332549 fr=171 per=87/161 [EST]
CANDIDATE 6
DNA (Note) PROTEIN: [NP_000172]
R-score = 0.054772; GO-score = 0.000017
61200000 bp Chromosome 7 77200000 bp
   
   
1 aa NP_611395 656 aa

Similarity found to protein:
[37197|NP_611395] | Drosophila melanogaster | CG15117-PB CG15117-PB | length=656 aa
GO annotation:
0.000000 beta-glucuronidase activity (function)
0.000000 carbohydrate metabolism (process)
0.000017 proteolysis (process)
0.000000 metallopeptidase activity (function)
0.000000 zinc ion binding (function)
BLASTX hits:
E-value 1e-23 prot=363..468 DNA=64883842..64883432 fr=656 per=59/137 [EST]