Analysis of Anorexia nervosa, susceptibility to
Analysis of Anorexia nervosa, susceptibility to G2D Home
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REASONS FOR ASSOCIATION OVERVIEW OF CANDIDATES BEST 10 CANDIDATES BEST 100 CANDIDATES

CHROMOSOMAL REGION
Disease mapped: Anorexia nervosa, susceptibility to
Method: Md
Chromosome: 1
Genomic position start-stop: 0-124200000
length: 124200001
Band: 1p
 LINKS

EntrezGene: [171514]

MEDLINE:

OMIM: [606788] XplorMed

REASONS FOR ASSOCIATION

MEDLINE QUERY
A set of 64 papers related to this disease was derived from MEDLINE using the query:
Anorexia [tw] AND susceptibility [tw]

MESH-C TERMS
The MeSH-C terms associated to the derived papers were collected.

Here you can see the terms ordered by the number of papers where they were found (number in brackets).

Disease Susceptibility [24]
Anorexia [11]
Genetic Predisposition to Disease [6]
Nutrition Disorders [6]
Dog Diseases [4]
Disease Models, Animal [4]
Amenorrhea [3]
Psychophysiologic Disorders [3]
Infection [3]
Dysentery, Bacillary [2]
We show here only the 10 most frequent. You can also see the complete list of 96 MeSH-C terms.

Each name is linked to the corresponding term description by the NLM. The number in brackets is linked to the list of papers that contained the term. The points to the related MeSH-D terms.

 GO terms
We computed the GO terms associated to the MeSH-C terms selected for this disease.

Here you can see those with higher score of association.

0.001005 regulation of synapse (process)
0.001005 cell (component)
0.001005 calcium channel regulator activity (function)
0.001005 feeding behavior (process)
0.000754 neuropeptide Y receptor activity (function)
0.000469 neuropeptide hormone activity (function)
0.000367 translation activator activity (function)
0.000359 B cell differentiation (process)
0.000347 luteinizing hormone-releasing factor activity (function)
0.000335 calcium ion transport (process)
We show here only the top 10. You can also see the complete list of 133 GO terms.

Each name is linked to the corresponding term description by GO. The number indicates the strength of association to Anorexia nervosa, susceptibility to. The points to the related MeSH-D terms.
Follow the green arrows to navigate MeSH-C / MeSH-D / GO-terms relationship derived from our analysis of the whole MEDLINE database, and used to relate the phenotype of this disease to terms of gene functionality.

OVERVIEW OF CANDIDATES IN THE REGION

The graph represents the BLASTX hits found in the region and the genes predicted or known in the region.

Legend:
BLASTX hits RefSeq genes Ensembl genes
                                                                                                                                             
> 1e-10 > 1e-20 > 1e-50 > 1e-80 > 1e-100 > 0
                 
         

Graph with GO scoring vs genomic position [PostScript graphic]

BEST SCORING 10 CANDIDATES
Here we show only the best scoring ten candidates but there are more. You can see the best scoring 100 candidates.

What is in a candidate?

CANDIDATE 1
DNA (Note) PROTEIN: [NP_002735] [NP_055927]

This candidate may be overlapping with a pseudogene (Note)
R-score = 0.000115; GO-score = 0.001005
0 bp Chromosome 1 124200000 bp
     
   
1 aa NP_036845 671 aa

Similarity found to protein:
[25023|NP_036845] | Rattus norvegicus | protein kinase C, beta 1 | length=671 aa
GO annotation:

0.000000 protein kinase activity (function)
0.000000 protein serine/threonine kinase activity (function)
0.000000 protein kinase CK2 activity (function)
0.000000 cAMP-dependent protein kinase activity (function)
0.000000 protein kinase C activity (function)
0.000000 protein-tyrosine kinase activity (function)
0.001005 calcium channel regulator activity (function)
0.000000 calcium ion binding (function)
0.000000 protein binding (function)
0.000000 ATP binding (function)
0.000000 nucleus (component)
0.000000 cytoplasm (component)
0.000000 plasma membrane (component)
0.000000 protein amino acid phosphorylation (process)
0.000335 calcium ion transport (process)
0.000000 calcium ion homeostasis (process)
0.000000 intracellular signaling cascade (process)
0.000017 membrane (component)
0.000000 transferase activity (function)
0.000000 diacylglycerol binding (function)
0.000000 regulation of growth (process)
BLASTX hits:
E-value 7e-18 prot=441..494 DNA=2135646..2135807 fr=671 per=35/54 [EST] [P]
E-value 7e-18 prot=489..520 DNA=2135900..2135995 fr=671 per=18/32 [EST] [P]
E-value 8e-12 prot=502..569 DNA=46206464..46206667 fr=671 per=33/68 [EST] [P]
CANDIDATE 2
DNA (Note) PROTEIN: [NP_000855] [NP_000862]

This candidate may be overlapping with a pseudogene (Note)
R-score = 0.000173; GO-score = 0.001005
0 bp Chromosome 1 124200000 bp
     
   
1 aa NP_036678 446 aa

Similarity found to protein:
[24316|NP_036678] | Rattus norvegicus | dopamine receptor 1A | length=446 aa
GO annotation:

0.000000 rhodopsin-like receptor activity (function)
0.000000 dopamine D1 receptor activity (function)
0.000090 G-protein coupled receptor activity (function)
0.000000 dopamine receptor activity (function)
0.001005 cell (component)
0.000000 membrane fraction (component)
0.000000 integral to plasma membrane (component)
0.000032 G-protein coupled receptor protein signaling pathway (process)
0.000221 G-protein signaling, coupled to cyclic nucleotide second messenger (process)
0.000000 adenylate cyclase activation (process)
0.000000 dopamine receptor, adenylate cyclase activating pathway (process)
0.000021 elevation of cytosolic calcium ion concentration (process)
0.000000 dopamine receptor signaling pathway (process)
0.000000 synaptic transmission (process)
0.000000 nervous system development (process)
0.000320 behavior (process)
0.000309 locomotory behavior (process)
0.000000 integral to membrane (component)
0.000000 transmission of nerve impulse (process)
0.000000 response to drug (process)
0.000000 eating behavior (process)
BLASTX hits:
E-value 5e-19 prot=31..231 DNA=19737656..19738228 fr=446 per=74/205 [EST] [P]
E-value 1e-44 prot=20..345 DNA=23265914..23264907 fr=446 per=121/360 [EST] [P]
CANDIDATE 3
DNA (Note) PROTEIN: [NP_000902]
R-score = 0.000633; GO-score = 0.001005
0 bp Chromosome 1 124200000 bp
   
   
1 aa NP_003605 368 aa

Similarity found to protein:
[8484|NP_003605] | Homo sapiens | galanin receptor 3 | length=368 aa
GO annotation:
0.000000 rhodopsin-like receptor activity (function)
0.000019 receptor activity (function)
0.000000 galanin receptor activity (function)
0.000000 plasma membrane (component)
0.000000 signal transduction (process)
0.000000 negative regulation of adenylate cyclase activity (process)
0.000062 neuropeptide signaling pathway (process)
0.000000 synaptic transmission (process)
0.000000 learning and/or memory (process)
0.001005 feeding behavior (process)
0.000000 integral to membrane (component)
BLASTX hits:
E-value 7e-11 prot=77..158 DNA=29006162..29006407 fr=368 per=35/82 [EST]
CANDIDATE 4
DNA (Note) PROTEIN: [NP_001516]
R-score = 0.000690; GO-score = 0.001005
0 bp Chromosome 1 124200000 bp
   
     
1 aa NP_037206 460 aa

Similarity found to protein:
[25605|NP_037206] | Rattus norvegicus | hypocretin receptor 2 | length=460 aa
GO annotation:
0.000000 rhodopsin-like receptor activity (function)
0.000090 G-protein coupled receptor activity (function)
0.000032 G-protein coupled receptor protein signaling pathway (process)
0.000062 neuropeptide signaling pathway (process)
0.001005 feeding behavior (process)
0.000000 integral to membrane (component)
0.000000 orexin receptor activity (function)
BLASTX hits:
E-value 2e-24 prot=128..216 DNA=31755517..31755783 fr=460 per=64/89 [EST]
E-value 1e-23 prot=75..172 DNA=31754226..31754579 fr=460 per=63/119 [EST]
E-value 3e-15 prot=254..328 DNA=31758215..31758445 fr=460 per=47/77 [EST]
E-value 3e-12 prot=320..370 DNA=31759666..31759818 fr=460 per=37/51 [EST]
CANDIDATE 5
DNA (Note) PROTEIN: [NP_005003] [NP_065387]

This candidate may be overlapping with a pseudogene (Note)
R-score = 0.000805; GO-score = 0.001005
0 bp Chromosome 1 124200000 bp
     
   
1 aa NP_036863 821 aa

Similarity found to protein:
[25054|NP_036863] | Rattus norvegicus | neurotrophic tyrosine kinase, receptor, type 2 | length=821 aa
GO annotation:

0.000000 protein kinase activity (function)
0.000000 protein-tyrosine kinase activity (function)
0.000000 transmembrane receptor protein tyrosine kinase activity (function)
0.000019 receptor activity (function)
0.000000 protein binding (function)
0.000000 ATP binding (function)
0.000000 cytosol (component)
0.000000 plasma membrane (component)
0.000000 integral to plasma membrane (component)
0.000000 protein amino acid phosphorylation (process)
0.000000 transmembrane receptor protein tyrosine kinase signaling pathway (process)
0.000000 nervous system development (process)
0.001005 feeding behavior (process)
0.000017 membrane (component)
0.000000 integral to membrane (component)
0.000000 kinase activity (function)
0.000000 transferase activity (function)
0.000287 regulation of metabolism (process)
0.000000 mechanoreceptor differentiation (process)
0.000000 neurotrophin binding (function)
0.000000 retinal rod cell development (process)
BLASTX hits:
E-value 5e-13 prot=714..812 DNA=22672470..22672853 fr=821 per=39/128 [EST] [P]
E-value 3e-64 prot=542..808 DNA=64355178..64355990 fr=821 per=130/273 [EST] [P]
CANDIDATE 6
DNA (Note) PROTEIN: [NP_001391] [NP_005272]

This candidate may be overlapping with a pseudogene (Note)
R-score = 0.000921; GO-score = 0.001005
0 bp Chromosome 1 124200000 bp
     
   
1 aa NP_058673 332 aa

Similarity found to protein:
[17202|NP_058673] | Mus musculus | melanocortin 4 receptor | length=332 aa
GO annotation:

0.000000 rhodopsin-like receptor activity (function)
0.000000 signal transducer activity (function)
0.000019 receptor activity (function)
0.000090 G-protein coupled receptor activity (function)
0.000105 melanocortin receptor activity (function)
0.000000 protein binding (function)
0.000000 signal transduction (process)
0.000032 G-protein coupled receptor protein signaling pathway (process)
0.001005 feeding behavior (process)
0.000000 integral to membrane (component)
0.000287 regulation of metabolism (process)
BLASTX hits:
E-value 2e-11 prot=55..318 DNA=27404596..27405384 fr=332 per=75/291 [EST] [P]
E-value 1e-21 prot=50..323 DNA=101416713..101417564 fr=332 per=81/293 [EST] [P]
CANDIDATE 7
DNA (Note) PROTEIN: [NP_284922] [NP_284923]
R-score = 0.001093; GO-score = 0.001005
0 bp Chromosome 1 124200000 bp
   
   
1 aa NP_036081 360 aa

Similarity found to protein:
[26416|NP_036081] | Mus musculus | mitogen activated protein kinase 14 | length=360 aa
GO annotation:
0.000000 DNA damage checkpoint (process)
0.000000 nucleotide binding (function)
0.000000 spindle pole (component)
0.000000 angiogenesis (process)
0.000000 protein kinase activity (function)
0.000000 protein serine/threonine kinase activity (function)
0.000000 MAP kinase activity (function)
0.000000 protein-tyrosine kinase activity (function)
0.000000 protein binding (function)
0.000000 ATP binding (function)
0.001005 cell (component)
0.000000 nucleus (component)
0.000000 cytoplasm (component)
0.000056 glucose metabolism (process)
0.000000 protein amino acid phosphorylation (process)
0.000000 response to stress (process)
0.000000 protein kinase cascade (process)
0.000000 striated muscle development (process)
0.000000 MP kinase activity (function)
0.000000 kinase activity (function)
0.000000 transferase activity (function)
0.000000 fatty acid oxidation (process)
0.000000 positive regulation of erythrocyte differentiation (process)
0.000000 positive regulation of transcription from RNA polymerase II promoter (process)
BLASTX hits:
E-value 3e-14 prot=200..238 DNA=1667539..1667423 fr=360 per=20/39 [EST]
E-value 3e-14 prot=127..166 DNA=1667941..1667822 fr=360 per=19/40 [EST]
E-value 3e-14 prot=164..195 DNA=1667754..1667650 fr=360 per=17/35 [EST]
CANDIDATE 8
DNA (Note) PROTEIN: [NP_002497]
R-score = 0.002186; GO-score = 0.001005
0 bp Chromosome 1 124200000 bp
   
  
1 aa NP_031566 249 aa

Similarity found to protein:
[12064|NP_031566] | Mus musculus | brain derived neurotrophic factor | length=249 aa
GO annotation:
0.000000 protein binding (function)
0.000000 extracellular space (component)
0.000015 anti-apoptosis (process)
0.000000 negative regulation of neuroblast proliferation (process)
0.000000 axon target recognition (process)
0.001005 feeding behavior (process)
0.000000 neuron recognition (process)
0.000000 growth factor activity (function)
0.000000 cytoplasmic membrane-bound vesicle (component)
0.000000 dendrite morphogenesis (process)
0.000287 regulation of metabolism (process)
0.000000 mechanoreceptor differentiation (process)
0.000000 positive regulation of neuron differentiation (process)
0.000000 regulation of retinal programmed cell death (process)
BLASTX hits:
E-value 3e-28 prot=87..249 DNA=115541228..115540743 fr=249 per=76/165 [EST]
CANDIDATE 9
DNA (Note) PROTEIN: [NP_000943]
R-score = 0.003682; GO-score = 0.000754
0 bp Chromosome 1 124200000 bp
   
   
1 aa NP_034044 359 aa

Similarity found to protein:
[12771|NP_034044] | Mus musculus | CC chemokine receptor 3 | length=359 aa
GO annotation:
0.000000 rhodopsin-like receptor activity (function)
0.000000 signal transducer activity (function)
0.000019 receptor activity (function)
0.000090 G-protein coupled receptor activity (function)
0.000754 neuropeptide Y receptor activity (function)
0.000000 protein binding (function)
0.000000 chemotaxis (process)
0.000000 defense response (process)
0.000000 signal transduction (process)
0.000032 G-protein coupled receptor protein signaling pathway (process)
0.000000 integral to membrane (component)
0.000000 C-C chemokine receptor activity (function)
0.000000 purinergic nucleotide receptor activity, G-protein coupled (function)
BLASTX hits:
E-value 2e-18 prot=40..321 DNA=28161627..28160749 fr=359 per=81/298 [EST]
CANDIDATE 10
DNA (Note) PROTEIN: [NP_001293]
R-score = 0.005696; GO-score = 0.000469
0 bp Chromosome 1 124200000 bp
   
  
1 aa NP_036967 112 aa

Similarity found to protein:
[25305|NP_036967] | Rattus norvegicus | cortistatin | length=112 aa
GO annotation:
0.000000 nucleosome (component)
0.000000 G-protein-coupled receptor binding (function)
0.000000 DNA binding (function)
0.000208 hormone activity (function)
0.000469 neuropeptide hormone activity (function)
0.000025 extracellular region (component)
0.000000 extracellular space (component)
0.000033 soluble fraction (component)
0.000000 nucleus (component)
0.000279 G-protein signaling, adenylate cyclase inhibiting pathway (process)
0.000062 neuropeptide signaling pathway (process)
0.000000 synaptic transmission (process)
0.000000 regulation of circadian sleep/wake cycle, sleep (process)
BLASTX hits:
E-value 8e-15 prot=42..112 DNA=10445704..10445916 fr=112 per=39/71 [EST]