Analysis of Allergic rhinitis
Analysis of Allergic rhinitis G2D Home
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REASONS FOR ASSOCIATION OVERVIEW OF CANDIDATES BEST 10 CANDIDATES ALL 53 CANDIDATES

CHROMOSOMAL REGION
Disease mapped: Allergic rhinitis
Method: Md
Chromosome: 4
Genomic position start-stop: 101400000-124300000
length: 22900001
Band: 4q24-q27
 LINKS

EntrezGene: [260328]

MEDLINE:

OMIM: [607154] XplorMed

REASONS FOR ASSOCIATION

MEDLINE QUERY
A set of 6247 papers related to this disease was derived from MEDLINE using the query:
Allergic [tw] AND rhinitis [tw]

MESH-C TERMS
The MeSH-C terms associated to the derived papers were collected.

Here you can see the terms ordered by the number of papers where they were found (number in brackets).

Rhinitis, Allergic, Perennial [2796]
Hay Fever [2450]
Asthma [1703]
Rhinitis [884]
Hypersensitivity [622]
Hypersensitivity, Immediate [392]
Respiratory Hypersensitivity [388]
Dermatitis, Atopic [289]
Chronic Disease [288]
Sinusitis [281]
We show here only the 10 most frequent. You can also see the complete list of 516 MeSH-C terms.

Each name is linked to the corresponding term description by the NLM. The number in brackets is linked to the list of papers that contained the term. The points to the related MeSH-D terms.

 GO terms
We computed the GO terms associated to the MeSH-C terms selected for this disease.

Here you can see those with higher score of association.

0.000687 interleukin-5 receptor activity (function)
0.000530 leukotriene-C4 synthase activity (function)
0.000353 glutathione metabolism (process)
0.000353 glutathione conjugation reaction (process)
0.000275 interleukin-5 receptor binding (function)
0.000275 cytokine binding (function)
0.000275 regulation of cell migration (process)
0.000265 gamma-glutamyltransferase activity (function)
0.000246 toxin resistance (process)
0.000229 hypersensitive response (process)
We show here only the top 10. You can also see the complete list of 42 GO terms.

Each name is linked to the corresponding term description by GO. The number indicates the strength of association to Allergic rhinitis. The points to the related MeSH-D terms.
Follow the green arrows to navigate MeSH-C / MeSH-D / GO-terms relationship derived from our analysis of the whole MEDLINE database, and used to relate the phenotype of this disease to terms of gene functionality.

OVERVIEW OF CANDIDATES IN THE REGION

The graph represents the BLASTX hits found in the region and the genes predicted or known in the region.

Legend:
BLASTX hits RefSeq genes Ensembl genes
                                                                         
> 1e-10 > 1e-20 > 1e-50 > 1e-80 > 1e-100 > 0
                                                                               
                                                                   

Graph with GO scoring vs genomic position [PostScript graphic]

BEST SCORING 10 CANDIDATES
Here we show only the best scoring ten candidates but there are more. You can see the best scoring 100 candidates.

What is in a candidate?

CANDIDATE 1
DNA (Note)
R-score = 0.002474; GO-score = 0.000275
101400000 bp Chromosome 4 124300000 bp
   
 
1 aa NP_035228 324 aa

Similarity found to protein:
[18741|NP_035228] | Mus musculus | paired-like homeodomain transcription factor 2 | length=324 aa
GO annotation:
0.000000 patterning of blood vessels (process)
0.000000 DNA binding (function)
0.000000 transcription factor activity (function)
0.000000 protein binding (function)
0.000000 nucleus (component)
0.000020 transcription factor complex (component)
0.000000 transcription (process)
0.000000 regulation of transcription, DNA-dependent (process)
0.000000 development (process)
0.000000 determination of left/right symmetry (process)
0.000000 pattern specification (process)
0.000000 heart development (process)
0.000000 Wnt receptor signaling pathway (process)
0.000275 regulation of cell migration (process)
0.000000 regulation of cell proliferation (process)
0.000000 regulation of transcription (process)
BLASTX hits:
E-value 3e-63 prot=135..324 DNA=111891907..111891338 fr=324 per=188/190 [EST]
E-value 6e-31 prot=68..138 DNA=111894583..111894371 fr=324 per=69/71 [EST]
E-value 1e-26 prot=1..70 DNA=111895670..111895461 fr=324 per=63/70 [EST]
CANDIDATE 2
DNA (Note)
R-score = 0.008803; GO-score = 0.000137
101400000 bp Chromosome 4 124300000 bp
   
   
1 aa NP_033604 431 aa

Similarity found to protein:
[22778|NP_033604] | Mus musculus | zinc finger protein, subfamily 1A, 1 (Ikaros) | length=431 aa
GO annotation:
0.000000 nucleic acid binding (function)
0.000000 DNA binding (function)
0.000000 transcription factor activity (function)
0.000000 protein binding (function)
0.000000 nucleus (component)
0.000020 transcription factor complex (component)
0.000000 transcription (process)
0.000000 regulation of transcription, DNA-dependent (process)
0.000000 zinc ion binding (function)
0.000137 hemopoiesis (process)
0.000000 forebrain development (process)
0.000000 positive regulation of transcription (process)
0.000000 positive regulation of transcription from RNA polymerase II promoter (process)
0.000000 metal ion binding (function)
BLASTX hits:
E-value 9e-11 prot=54..133 DNA=111690554..111690793 fr=431 per=31/80 [EST]
CANDIDATE 3
DNA (Note)
R-score = 0.011219; GO-score = 0.000092
101400000 bp Chromosome 4 124300000 bp
   
  
1 aa NP_032903 812 aa

Similarity found to protein:
[18815|NP_032903] | Mus musculus | plasminogen | length=812 aa
GO annotation:
0.000000 serine-type endopeptidase activity (function)
0.000000 plasmin activity (function)
0.000092 hormone activity (function)
0.000000 calcium ion binding (function)
0.000000 extracellular region (component)
0.000000 extracellular space (component)
0.000000 proteolysis (process)
0.000000 apoptosis (process)
0.000000 induction of apoptosis (process)
0.000000 blood coagulation (process)
0.000000 peptidase activity (function)
0.000000 tissue development (process)
0.000000 negative regulation of angiogenesis (process)
0.000000 hydrolase activity (function)
0.000000 tissue regeneration (process)
0.000000 fibrinolysis (process)
0.000000 myoblast differentiation (process)
0.000000 muscle maintenance (process)
0.000000 organismal physiological process (process)
BLASTX hits:
E-value 7e-13 prot=718..806 DNA=119555031..119554762 fr=812 per=42/92 [EST]
CANDIDATE 4
DNA (Note) PROTEIN: [NP_005899]

This candidate may be overlapping with a pseudogene (Note)
R-score = 0.020827; GO-score = 0.000053
101400000 bp Chromosome 4 124300000 bp
     
   
1 aa NP_006112 644 aa

Similarity found to protein:
[3848|NP_006112] | Homo sapiens | keratin 1 | length=644 aa
GO annotation:

0.000000 complement activation, lectin pathway (process)
0.000000 receptor activity (function)
0.000000 structural molecule activity (function)
0.000000 structural constituent of cytoskeleton (function)
0.000000 protein binding (function)
0.000000 sugar binding (function)
0.000000 cytoskeleton (component)
0.000000 intermediate filament (component)
0.000053 response to oxidative stress (process)
0.000000 epidermis development (process)
0.000000 membrane (component)
0.000000 fibrinolysis (process)
0.000000 regulation of angiogenesis (process)
BLASTX hits:
E-value 4e-86 prot=152..289 DNA=104003141..104002734 fr=644 per=78/138 [EST] [P]
E-value 4e-86 prot=288..433 DNA=104002740..104002303 fr=644 per=74/146 [EST] [P]
E-value 4e-86 prot=436..508 DNA=104002297..104002082 fr=644 per=44/73 [EST] [P]
E-value 2e-23 prot=180..511 DNA=117193836..117194822 fr=644 per=87/333 [EST] [P]
CANDIDATE 5
DNA (Note)
R-score = 0.023359; GO-score = 0.000053
101400000 bp Chromosome 4 124300000 bp
   
     
1 aa NP_031975 760 aa

Similarity found to protein:
[13871|NP_031975] | Mus musculus | excision repair cross-complementing rodent repair deficiency, complementation group 2 | length=760 aa
GO annotation:
0.000000 nucleotide binding (function)
0.000000 magnesium ion binding (function)
0.000000 nucleic acid binding (function)
0.000000 DNA binding (function)
0.000000 ATP-dependent DNA helicase activity (function)
0.000000 helicase activity (function)
0.000000 ATP binding (function)
0.000000 nucleus (component)
0.000000 nucleobase, nucleoside, nucleotide and nucleic acid metabolism (process)
0.000000 DNA repair (process)
0.000000 nucleotide-excision repair (process)
0.000000 transcription (process)
0.000000 regulation of transcription, DNA-dependent (process)
0.000000 response to DNA damage stimulus (process)
0.000053 response to oxidative stress (process)
0.000000 aging (process)
0.000000 ATP-dependent helicase activity (function)
0.000000 post-embryonic development (process)
0.000000 hydrolase activity (function)
0.000000 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (function)
BLASTX hits:
E-value 3e-15 prot=593..727 DNA=113631075..113631473 fr=760 per=41/135 [EST]
E-value 3e-15 prot=432..584 DNA=113630582..113631043 fr=760 per=42/168 [EST]
CANDIDATE 6
DNA (Note)
R-score = 0.023992; GO-score = 0.000051
101400000 bp Chromosome 4 124300000 bp
  
   
1 aa NP_062178 154 aa

Similarity found to protein:
[54250|NP_062178] | Rattus norvegicus | fibroblast growth factor 2 | length=154 aa
GO annotation:
0.000000 regulation of progression through cell cycle (process)
0.000000 activation of MAPK activity (process)
0.000000 nuclear translocation of MAPK (process)
0.000000 angiogenesis (process)
0.000000 induction of an organ (process)
0.000000 fibroblast growth factor receptor binding (function)
0.000000 nerve growth factor receptor binding (function)
0.000000 voltage-gated calcium channel activity (function)
0.000000 protein binding (function)
0.000000 extracellular space (component)
0.000000 cytoplasm (component)
0.000000 regulation of transcription, DNA-dependent (process)
0.000000 C21-steroid hormone biosynthesis (process)
0.000027 chemotaxis (process)
0.000000 signal transduction (process)
0.000051 protein kinase cascade (process)
0.000000 Ras protein signal transduction (process)
0.000000 cell-cell signaling (process)
0.000000 synaptic transmission (process)
0.000000 nervous system development (process)
0.000000 muscle development (process)
0.000000 growth factor activity (function)
0.000000 heparin binding (function)
0.000000 cell proliferation (process)
0.000000 positive regulation of cell proliferation (process)
0.000000 glial cell differentiation (process)
0.000000 regulation of calcium ion-dependent exocytosis (process)
0.000000 negative regulation of cell growth (process)
0.000000 lung development (process)
0.000000 positive regulation of cell differentiation (process)
0.000000 negative regulation of transcription, DNA-dependent (process)
0.000000 positive regulation of transcription (process)
0.000000 regulation of retinal programmed cell death (process)
BLASTX hits:
E-value 1e-26 prot=94..154 DNA=124164771..124164953 fr=154 per=59/61 [EST]
E-value 3e-25 prot=1..58 DNA=124099735..124099911 fr=154 per=57/59 [EST]
CANDIDATE 7
DNA (Note)

This candidate may be overlapping with a pseudogene (Note)
R-score = 0.024970; GO-score = 0.000051
101400000 bp Chromosome 4 124300000 bp
   
           
1 aa NP_036974 1133 aa

Similarity found to protein:
[25313|NP_036974] | Rattus norvegicus | epidermal growth factor | length=1133 aa
GO annotation:

0.000000 activation of MAPK activity (process)
0.000000 epidermal growth factor receptor binding (function)
0.000000 epidermal growth factor receptor activating ligand activity (function)
0.000000 calcium ion binding (function)
0.000000 extracellular region (component)
0.000000 extracellular space (component)
0.000000 nucleus (component)
0.000000 plasma membrane (component)
0.000000 DNA replication (process)
0.000000 chromosome organization and biogenesis (sensu Eukaryota) (process)
0.000000 epidermal growth factor receptor signaling pathway (process)
0.000051 protein kinase cascade (process)
0.000000 growth factor activity (function)
0.000000 positive regulation of cell proliferation (process)
0.000000 membrane (component)
0.000000 integral to membrane (component)
0.000000 peptidyl-tyrosine phosphorylation (process)
0.000000 regulation of protein secretion (process)
0.000000 regulation of peptidyl-tyrosine phosphorylation (process)
BLASTX hits:
E-value 2e-27 prot=612..695 DNA=111249220..111249471 fr=1133 per=63/84 [EST] [P]
E-value 2e-22 prot=44..110 DNA=111214155..111214355 fr=1133 per=53/67 [EST] [P]
E-value 4e-21 prot=687..743 DNA=111253181..111253351 fr=1133 per=49/57 [EST] [P]
E-value 2e-17 prot=171..251 DNA=111217050..111217292 fr=1133 per=47/81 [EST] [P]
E-value 8e-17 prot=528..577 DNA=111242181..111242330 fr=1133 per=43/50 [EST] [P]
E-value 8e-17 prot=482..530 DNA=111237610..111237756 fr=1133 per=42/49 [EST] [P]
E-value 2e-16 prot=354..397 DNA=111234067..111234198 fr=1133 per=37/44 [EST] [P]
E-value 3e-14 prot=110..178 DNA=111216461..111216670 fr=1133 per=38/70 [EST] [P]
E-value 3e-13 prot=871..915 DNA=111261784..111261918 fr=1133 per=34/45 [EST] [P]
E-value 4e-13 prot=743..794 DNA=111254035..111254190 fr=1133 per=35/52 [EST] [P]
E-value 1e-11 prot=398..439 DNA=111235072..111235197 fr=1133 per=32/42 [EST] [P]
CANDIDATE 8
DNA (Note)
R-score = 0.034923; GO-score = 0.000040
101400000 bp Chromosome 4 124300000 bp
   
   
1 aa NP_034350 456 aa

Similarity found to protein:
[14229|NP_034350] | Mus musculus | FK506 binding protein 5 | length=456 aa
GO annotation:
0.000000 peptidyl-prolyl cis-trans isomerase activity (function)
0.000040 binding (function)
0.000000 nucleus (component)
0.000000 protein folding (process)
0.000000 isomerase activity (function)
0.000000 unfolded protein binding (function)
BLASTX hits:
E-value 2e-89 prot=16..415 DNA=119467514..119466339 fr=456 per=181/405 [EST]
CANDIDATE 9
DNA (Note)
R-score = 0.041367; GO-score = 0.000040
101400000 bp Chromosome 4 124300000 bp
   
   
1 aa NP_032006 132 aa

Similarity found to protein:
[14079|NP_032006] | Mus musculus | fatty acid binding protein 2, intestinal | length=132 aa
GO annotation:
0.000040 binding (function)
0.000000 transport (process)
0.000000 lipid binding (function)
BLASTX hits:
E-value 2e-18 prot=23..79 DNA=120593601..120593431 fr=132 per=47/57 [EST]
CANDIDATE 10
DNA (Note)
R-score = 0.047811; GO-score = 0.000040
101400000 bp Chromosome 4 124300000 bp
   
   
1 aa NP_037200 132 aa

Similarity found to protein:
[25598|NP_037200] | Rattus norvegicus | fatty acid binding protein 1 | length=132 aa
GO annotation:
0.000000 transporter activity (function)
0.000000 lipid transporter activity (function)
0.000040 binding (function)
0.000000 fatty acid binding (function)
0.000000 plasma membrane (component)
0.000000 fatty acid metabolism (process)
0.000000 transport (process)
0.000000 digestion (process)
0.000000 lipid binding (function)
0.000000 fatty acid transport (process)
BLASTX hits:
E-value 7e-19 prot=23..79 DNA=120593601..120593431 fr=132 per=49/57 [EST]