Analysis of Abdominal obesity-metabolic syndrome QTL1
Analysis of Abdominal obesity-metabolic syndrome QTL1 G2D Home
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REASONS FOR ASSOCIATION OVERVIEW OF CANDIDATES BEST 10 CANDIDATES BEST 100 CANDIDATES

CHROMOSOMAL REGION
Disease mapped: Abdominal obesity-metabolic syndrome QTL1
Method: Md
Chromosome: 3
Genomic position start-stop: 181850000-191850000
length: 10000001
Band: 3q27
 LINKS

EntrezGene: [65076]

MEDLINE:

OMIM: [605552] XplorMed

REASONS FOR ASSOCIATION

MEDLINE QUERY
A set of 383 papers related to this disease was derived from MEDLINE using the query:
Abdominal [tw] AND obesity [tw] AND metabolic [tw]

MESH-C TERMS
The MeSH-C terms associated to the derived papers were collected.

Here you can see the terms ordered by the number of papers where they were found (number in brackets).

Obesity [304]
Diabetes Mellitus, Non-Insulin-Dependent [66]
Cardiovascular Diseases [47]
Hypertension [42]
Hyperlipidemia [26]
Coronary Disease [26]
Obesity in Diabetes [21]
Syndrome [18]
Polycystic Ovary Syndrome [15]
Diabetes Mellitus [15]
We show here only the 10 most frequent. You can also see the complete list of 119 MeSH-C terms.

Each name is linked to the corresponding term description by the NLM. The number in brackets is linked to the list of papers that contained the term. The points to the related MeSH-D terms.

 GO terms
We computed the GO terms associated to the MeSH-C terms selected for this disease.

Here you can see those with higher score of association.

0.003013 insulin receptor signaling pathway (process)
0.002630 regulation of metabolism (process)
0.002516 triglyceride binding (function)
0.002237 cAMP-dependent protein kinase regulator activity (function)
0.002141 peptidyl-dipeptidase activity (function)
0.002107 thyroid hormone receptor activity (function)
0.002093 calcium channel regulator activity (function)
0.002093 cell (component)
0.002093 regulation of synapse (process)
0.002093 feeding behavior (process)
We show here only the top 10. You can also see the complete list of 637 GO terms.

Each name is linked to the corresponding term description by GO. The number indicates the strength of association to Abdominal obesity-metabolic syndrome QTL1. The points to the related MeSH-D terms.
Follow the green arrows to navigate MeSH-C / MeSH-D / GO-terms relationship derived from our analysis of the whole MEDLINE database, and used to relate the phenotype of this disease to terms of gene functionality.

OVERVIEW OF CANDIDATES IN THE REGION

The graph represents the BLASTX hits found in the region and the genes predicted or known in the region.

Legend:
BLASTX hits RefSeq genes Ensembl genes
                                                                                                       
> 1e-10 > 1e-20 > 1e-50 > 1e-80 > 1e-100 > 0
                                       
                                       

Graph with GO scoring vs genomic position [PostScript graphic]

BEST SCORING 10 CANDIDATES
Here we show only the best scoring ten candidates but there are more. You can see the best scoring 100 candidates.

What is in a candidate?

CANDIDATE 1
DNA (Note) PROTEIN: [NP_004434]
R-score = 0.000173; GO-score = 0.003013
181850000 bp Chromosome 3 191850000 bp
   
   
1 aa NP_000866 1367 aa

Similarity found to protein:
[3480|NP_000866] | Homo sapiens | insulin-like growth factor 1 receptor precursor | length=1367 aa
GO annotation:
0.000057 regulation of progression through cell cycle (process)
0.000000 nucleotide binding (function)
0.000107 protein serine/threonine kinase activity (function)
0.000158 receptor activity (function)
0.000000 epidermal growth factor receptor activity (function)
0.000627 insulin-like growth factor receptor activity (function)
0.000262 protein binding (function)
0.000106 ATP binding (function)
0.000204 protein amino acid phosphorylation (process)
0.000277 anti-apoptosis (process)
0.000335 signal transduction (process)
0.000493 positive regulation of cell proliferation (process)
0.003013 insulin receptor signaling pathway (process)
0.000153 membrane (component)
0.000118 integral to membrane (component)
0.000000 transferase activity (function)
BLASTX hits:
E-value 1e-18 prot=1111..1266 DNA=185780920..185781600 fr=1367 per=64/227 [EST]
CANDIDATE 2
DNA (Note) PROTEIN: [NP_624302]
R-score = 0.009838; GO-score = 0.001973
181850000 bp Chromosome 3 191850000 bp
   
   
1 aa NP_031378 270 aa

Similarity found to protein:
[23436|NP_031378] | Homo sapiens | elastase 3B | length=270 aa
GO annotation:
0.000207 extracellular region (component)
0.000047 proteolysis (process)
0.000000 pancreatic elastase I activity (function)
0.001973 cholesterol metabolism (process)
0.000000 peptidase activity (function)
BLASTX hits:
E-value 5e-12 prot=20..265 DNA=188437047..188436223 fr=270 per=80/284 [EST]
CANDIDATE 3
DNA (Note) PROTEIN: [NP_004788]
R-score = 0.019504; GO-score = 0.001263
181850000 bp Chromosome 3 191850000 bp
   
  
1 aa NP_033735 247 aa

Similarity found to protein:
[11450|NP_033735] | Mus musculus | adipocyte complement related protein | length=247 aa
GO annotation:
0.000215 receptor binding (function)
0.000689 hormone activity (function)
0.000262 protein binding (function)
0.000180 extracellular space (component)
0.000207 cytoplasm (component)
0.000118 endoplasmic reticulum (component)
0.001263 glucose metabolism (process)
0.000485 fatty acid beta-oxidation (process)
0.000000 phosphate transport (process)
0.000000 response to glucose stimulus (process)
0.000000 positive regulation of signal transduction (process)
0.000000 fatty acid oxidation (process)
0.000000 glucose homeostasis (process)
0.000000 positive regulation of I-kappaB kinase/NF-kappaB cascade (process)
0.000000 negative regulation of gluconeogenesis (process)
0.000000 positive regulation of fatty acid metabolism (process)
0.000000 positive regulation of glucose import (process)
0.000000 protein homooligomerization (process)
BLASTX hits:
E-value 5e-86 prot=77..247 DNA=188054681..188055193 fr=247 per=150/171 [EST]
CANDIDATE 4
DNA (Note)
R-score = 0.023359; GO-score = 0.001258
181850000 bp Chromosome 3 191850000 bp
   
    
1 aa NP_003552 165 aa

Similarity found to protein:
[8399|NP_003552] | Homo sapiens | phospholipase A2, group X | length=165 aa
GO annotation:
0.000580 phospholipase A2 activity (function)
0.000155 calcium ion binding (function)
0.000207 extracellular region (component)
0.001258 lipid catabolism (process)
0.000000 hydrolase activity (function)
BLASTX hits:
E-value 4e-39 prot=27..83 DNA=183892467..183892637 fr=165 per=42/57 [EST]
E-value 4e-39 prot=117..165 DNA=183892630..183892776 fr=165 per=42/49 [EST]
CANDIDATE 5
DNA (Note) PROTEIN: [NP_640341]
R-score = 0.023819; GO-score = 0.001258
181850000 bp Chromosome 3 191850000 bp
   
       
1 aa NP_700453 421 aa

Similarity found to protein:
[239759|NP_700453] | Mus musculus | lipase, member H | length=421 aa
GO annotation:
0.000157 catalytic activity (function)
0.000207 extracellular region (component)
0.000180 extracellular space (component)
0.000501 lipid metabolism (process)
0.001258 lipid catabolism (process)
BLASTX hits:
E-value 1e-52 prot=16..141 DNA=186735627..186735250 fr=421 per=100/126 [EST]
E-value 9e-19 prot=336..393 DNA=186712187..186712014 fr=421 per=46/58 [EST]
E-value 7e-18 prot=210..266 DNA=186719801..186719631 fr=421 per=41/57 [EST]
CANDIDATE 6
DNA (Note)
R-score = 0.024164; GO-score = 0.001258
181850000 bp Chromosome 3 191850000 bp
   
    
1 aa NP_036117 151 aa

Similarity found to protein:
[26565|NP_036117] | Mus musculus | phospholipase A2, group X | length=151 aa
GO annotation:
0.000580 phospholipase A2 activity (function)
0.000155 calcium ion binding (function)
0.000180 extracellular space (component)
0.001258 lipid catabolism (process)
0.000000 hydrolase activity (function)
0.000000 metal ion binding (function)
BLASTX hits:
E-value 4e-33 prot=11..69 DNA=183892461..183892637 fr=151 per=37/59 [EST]
E-value 4e-33 prot=103..151 DNA=183892630..183892776 fr=151 per=33/49 [EST]
CANDIDATE 7
DNA (Note) PROTEIN: [NP_001957]
R-score = 0.032334; GO-score = 0.001065
181850000 bp Chromosome 3 191850000 bp
   
 
1 aa NP_076226 284 aa

Similarity found to protein:
[74147|NP_076226] | Mus musculus | L-specific multifunctional beta-oxdiation protein | length=284 aa
GO annotation:
0.000157 catalytic activity (function)
0.000115 3-hydroxyacyl-CoA dehydrogenase activity (function)
0.000000 dodecenoyl-CoA delta-isomerase activity (function)
0.000000 enoyl-CoA hydratase activity (function)
0.000044 mitochondrion (component)
0.000446 peroxisome (component)
0.000501 lipid metabolism (process)
0.000647 fatty acid metabolism (process)
0.000485 fatty acid beta-oxidation (process)
0.001065 acyl-CoA metabolism (process)
0.000425 metabolism (process)
0.000000 oxidoreductase activity (function)
0.000000 lyase activity (function)
0.000000 isomerase activity (function)
BLASTX hits:
E-value 1e-123 prot=1..284 DNA=186393571..186392720 fr=284 per=241/284 [EST]
CANDIDATE 8
DNA (Note)
R-score = 0.037800; GO-score = 0.000961
181850000 bp Chromosome 3 191850000 bp
   
   
1 aa NP_066267 4377 aa

Similarity found to protein:
[288|NP_066267] | Homo sapiens | ankyrin 3 isoform 2 | length=4377 aa
GO annotation:
0.000027 structural constituent of cytoskeleton (function)
0.000262 protein binding (function)
0.000025 molecular function unknown (function)
0.000118 endoplasmic reticulum (component)
0.000033 Golgi apparatus (component)
0.000039 cytoskeleton (component)
0.000961 protein targeting (process)
0.000000 cytoskeletal anchoring (process)
0.000335 signal transduction (process)
0.000000 cellular component unknown (component)
BLASTX hits:
E-value 1e-16 prot=567..710 DNA=187961715..187962146 fr=4377 per=52/144 [EST]
E-value 8e-15 prot=333..480 DNA=187961706..187962149 fr=4377 per=51/148 [EST]
E-value 3e-14 prot=534..678 DNA=187961715..187962149 fr=4377 per=48/145 [EST]
E-value 1e-13 prot=462..623 DNA=187961697..187962161 fr=4377 per=55/162 [EST]
E-value 1e-13 prot=267..414 DNA=187961706..187962149 fr=4377 per=48/148 [EST]
E-value 8e-12 prot=399..542 DNA=187961706..187962137 fr=4377 per=46/144 [EST]
E-value 2e-11 prot=630..773 DNA=187961706..187962137 fr=4377 per=44/144 [EST]
E-value 2e-11 prot=435..579 DNA=187961715..187962149 fr=4377 per=47/145 [EST]
E-value 7e-11 prot=498..645 DNA=187961706..187962149 fr=4377 per=45/148 [EST]
CANDIDATE 9
DNA (Note) PROTEIN: [NP_001039]
R-score = 0.064783; GO-score = 0.000689
181850000 bp Chromosome 3 191850000 bp
   
  
1 aa NP_036791 116 aa

Similarity found to protein:
[24797|NP_036791] | Rattus norvegicus | somatostatin | length=116 aa
GO annotation:
0.000689 hormone activity (function)
0.000207 extracellular region (component)
0.000180 extracellular space (component)
0.000000 regulation of cell migration (process)
BLASTX hits:
E-value 2e-30 prot=46..114 DNA=188869771..188869565 fr=116 per=68/69 [EST]
E-value 2e-13 prot=1..46 DNA=188870782..188870645 fr=116 per=43/46 [EST]
CANDIDATE 10
DNA (Note) PROTEIN: [NP_000451] (Itself) [NP_954698] [NP_955388]
R-score = 0.067430; GO-score = 0.000689
181850000 bp Chromosome 3 191850000 bp
   
  
1 aa NP_000451 353 aa

Similarity found to protein:
[7066|NP_000451] | Homo sapiens | thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor) | length=353 aa
GO annotation:
0.000000 cytokine activity (function)
0.000689 hormone activity (function)
0.000180 extracellular space (component)
0.000226 development (process)
0.000037 growth factor activity (function)
0.000120 cell proliferation (process)
BLASTX hits:
E-value 2e-98 prot=121..353 DNA=185573705..185573007 fr=353 per=225/233 [EST]