Analysis of Asthma chr4
Analysis of Asthma chr4 G2D Home
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REASONS FOR ASSOCIATION OVERVIEW OF CANDIDATES BEST 10 CANDIDATES BEST 100 CANDIDATES

CHROMOSOMAL REGION
Disease mapped: Asthma chr4
Method: Md
Chromosome: 4
Genomic position start-stop: 0-13401795
length: 13401796
Band: p16.3-p15.33
 LINKS

EntrezGene: no link

MEDLINE:

OMIM: no link

REASONS FOR ASSOCIATION

MEDLINE QUERY
A set of 4317 papers related to asthma was derived from MEDLINE using the query:
Asthma [MH] AND Case Report [MH]

MESH-C TERMS
The MeSH-C terms associated to the derived papers were collected and manually filtered.

Here you can see the terms ordered by the fraction of papers where they were found.

Asthma [0.957365269461078]
Status Asthmaticus [0.0548502994011976]
Drug Hypersensitivity [0.0431137724550898]
Bronchial Spasm [0.0304191616766467]
Eosinophilia [0.0297005988023952]
Bronchitis [0.0239520958083832]
Airway Obstruction [0.0239520958083832]
Rhinitis [0.0208383233532934]
Food Hypersensitivity [0.0205988023952096]
Anaphylaxis [0.0203592814371257]
We show here only the 10 most frequent. You can also see the complete list of 50 MeSH-C terms.

Each name is linked to the corresponding term description by the NLM. The number in brackets is linked to the list of papers that contained the term. The points to the related MeSH-D terms.

 GO terms
We computed the GO terms associated to the MeSH-C terms selected for this disease.

Here you can see those with higher score of association.

0.000797 peptidyl-dipeptidase activity (function)
0.000404 interleukin-5 receptor activity (function)
0.000356 fluid secretion (process)
0.000291 peroxidase activity (function)
0.000283 protein kinase inhibitor activity (function)
0.000261 pancreatic elastase activity (function)
0.000233 leukotriene-C4 synthase activity (function)
0.000230 renin activity (function)
0.000230 cathepsin D activity (function)
0.000228 angiotensin type II receptor activity (function)
We show here only the top 10. You can also see the complete list of 2490 GO terms.

Each name is linked to the corresponding term description by GO. The number indicates the strength of association to Asthma chr4. The points to the related MeSH-D terms.
Follow the green arrows to navigate MeSH-C / MeSH-D / GO-terms relationship derived from our analysis of the whole MEDLINE database, and used to relate the phenotype of this disease to terms of gene functionality.

OVERVIEW OF CANDIDATES IN THE REGION

The graph represents the BLASTX hits found in the region and the genes predicted or known in the region.

Legend:
BLASTX hits RefSeq genes Ensembl genes
                                                                                                                           
> 1e-10 > 1e-20 > 1e-50 > 1e-80 > 1e-100 > 0
                                       
                               

Graph with GO scoring vs genomic position [PostScript graphic]

BEST SCORING 10 CANDIDATES
Here we show only the best scoring ten candidates but there are more. You can see the best scoring 100 candidates.

What is in a candidate?

CANDIDATE 1
DNA (Note) PROTEIN: [NP_000674] [NP_000789]

This candidate may be overlapping with a pseudogene (Note)
R-score = 0.006329; GO-score = 0.000207
0 bp Chromosome 4 13401795 bp
     
   
1 aa NP_036624 418 aa

Similarity found to protein:
[24176|NP_036624] | Rattus norvegicus | adrenergic receptor, beta 2 | length=418 aa
GO annotation:

0.000024 activation of MAPK activity (process)
0.000000 rhodopsin-like receptor activity (function)
0.000008 receptor activity (function)
0.000013 G-protein coupled receptor activity (function)
0.000000 adrenoceptor activity (function)
0.000058 beta-adrenergic receptor activity (function)
0.000048 beta2-adrenergic receptor activity (function)
0.000017 lysosome (component)
0.000016 endosome (component)
0.000015 integral to plasma membrane (component)
0.000015 receptor mediated endocytosis (process)
0.000044 transmembrane receptor protein tyrosine kinase activation (dimerization) (process)
0.000032 G-protein coupled receptor protein signaling pathway (process)
0.000027 G-protein signaling, coupled to cAMP nucleotide second messenger (process)
0.000020 adenylate cyclase activation (process)
0.000022 protein kinase cascade (process)
0.000037 respiratory gaseous exchange (process)
0.000207 blood pressure regulation (process)
0.000040 endosome to lysosome transport (process)
0.000005 integral to membrane (component)
0.000000 apical plasma membrane (component)
BLASTX hits:
E-value 9e-21 prot=64..235 DNA=3805547..3806041 fr=418 per=58/172 [EST] [P]
E-value 1e-48 prot=50..349 DNA=9460092..9461069 fr=418 per=117/330 [EST] [P]
CANDIDATE 2
DNA (Note) PROTEIN: [NP_002102] (Itself)
R-score = 0.011219; GO-score = 0.000164
0 bp Chromosome 4 13401795 bp
   
    
1 aa NP_002102 3144 aa

Similarity found to protein:
[3064|NP_002102] | Homo sapiens | huntingtin | length=3144 aa
GO annotation:
0.000012 transcription corepressor activity (function)
0.000007 transporter activity (function)
0.000005 protein binding (function)
0.000002 molecular function unknown (function)
0.000008 soluble fraction (component)
0.000003 nucleus (component)
0.000005 cytoplasm (component)
0.000029 apoptosis (process)
0.000015 induction of apoptosis (process)
0.000164 behavior (process)
0.000007 microtubule binding (function)
0.000012 pathogenesis (process)
0.000000 organ morphogenesis (process)
BLASTX hits:
E-value 2e-46 prot=463..584 DNA=3165974..3166339 fr=3144 per=117/122 [EST]
E-value 4e-37 prot=748..833 DNA=3171293..3171643 fr=3144 per=86/117 [EST]
E-value 9e-35 prot=1666..1749 DNA=3226382..3226633 fr=3144 per=80/84 [EST]
E-value 3e-34 prot=1302..1391 DNA=3211594..3211863 fr=3144 per=79/90 [EST]
E-value 4e-33 prot=3058..3144 DNA=3278511..3278753 fr=3144 per=75/87 [EST]
E-value 4e-32 prot=2141..2212 DNA=3250660..3250875 fr=3144 per=72/72 [EST]
E-value 3e-30 prot=1099..1168 DNA=3186729..3186938 fr=3144 per=68/70 [EST]
E-value 9e-27 prot=2258..2319 DNA=3252680..3252865 fr=3144 per=60/62 [EST]
E-value 2e-26 prot=2354..2435 DNA=3256495..3256740 fr=3144 per=68/82 [EST]
E-value 4e-26 prot=1909..1968 DNA=3245227..3245406 fr=3144 per=60/60 [EST]
E-value 2e-25 prot=2758..2820 DNA=3271860..3272048 fr=3144 per=63/63 [EST]
E-value 5e-25 prot=1792..1861 DNA=3238462..3238671 fr=3144 per=70/70 [EST]
E-value 8e-25 prot=2966..3049 DNA=3277142..3277393 fr=3144 per=67/86 [EST]
E-value 9e-24 prot=1969..2027 DNA=3245538..3245714 fr=3144 per=59/59 [EST]
E-value 1e-23 prot=359..426 DNA=3159960..3160163 fr=3144 per=68/68 [EST]
E-value 2e-23 prot=2858..2945 DNA=3274256..3274516 fr=3144 per=77/88 [EST]
E-value 1e-22 prot=3020..3089 DNA=3277512..3277721 fr=3144 per=56/70 [EST]
E-value 5e-20 prot=2492..2545 DNA=3262134..3262295 fr=3144 per=53/54 [EST]
E-value 6e-20 prot=1484..1539 DNA=3217009..3217176 fr=3144 per=52/56 [EST]
E-value 8e-20 prot=934..984 DNA=3179236..3179388 fr=3144 per=50/51 [EST]
E-value 1e-19 prot=2706..2779 DNA=3268584..3268796 fr=3144 per=57/74 [EST]
E-value 1e-18 prot=205..262 DNA=3146015..3146188 fr=3144 per=50/58 [EST]
E-value 2e-18 prot=1051..1102 DNA=3185529..3185684 fr=3144 per=50/52 [EST]
E-value 2e-18 prot=2212..2285 DNA=3251294..3251473 fr=3144 per=53/74 [EST]
E-value 4e-18 prot=825..885 DNA=3173103..3173288 fr=3144 per=53/62 [EST]
E-value 2e-17 prot=1533..1591 DNA=3219224..3219400 fr=3144 per=50/59 [EST]
E-value 2e-17 prot=1861..1908 DNA=3242736..3242879 fr=3144 per=47/48 [EST]
E-value 4e-17 prot=2417..2459 DNA=3258913..3259041 fr=3144 per=43/43 [EST]
E-value 1e-16 prot=2541..2588 DNA=3262712..3262855 fr=3144 per=46/48 [EST]
E-value 2e-16 prot=702..747 DNA=3170369..3170506 fr=3144 per=46/46 [EST]
E-value 5e-16 prot=255..299 DNA=3154045..3154179 fr=3144 per=45/45 [EST]
E-value 1e-15 prot=1211..1254 DNA=3195802..3195933 fr=3144 per=44/44 [EST]
E-value 6e-21 prot=2657..2706 DNA=3267560..3267709 fr=3144 per=45/50 [EST]
E-value 3e-15 prot=2075..2140 DNA=3248483..3248680 fr=3144 per=46/66 [EST]
E-value 3e-15 prot=1750..1792 DNA=3227698..3227826 fr=3144 per=43/43 [EST]
E-value 4e-15 prot=1624..1669 DNA=3225325..3225462 fr=3144 per=44/46 [EST]
E-value 8e-15 prot=2816..2868 DNA=3273964..3274122 fr=3144 per=43/53 [EST]
E-value 4e-14 prot=584..626 DNA=3168656..3168784 fr=3144 per=41/43 [EST]
E-value 8e-14 prot=625..664 DNA=3169036..3169155 fr=3144 per=40/40 [EST]
E-value 1e-13 prot=118..158 DNA=3138004..3138126 fr=3144 per=41/41 [EST]
E-value 5e-13 prot=982..1024 DNA=3181489..3181617 fr=3144 per=41/43 [EST]
E-value 9e-13 prot=1586..1625 DNA=3221085..3221204 fr=3144 per=39/40 [EST]
E-value 1e-12 prot=299..359 DNA=3154816..3154998 fr=3144 per=61/61 [EST]
E-value 3e-12 prot=665..701 DNA=3170018..3170128 fr=3144 per=37/37 [EST]
E-value 2e-11 prot=2458..2507 DNA=3261114..3261263 fr=3144 per=38/50 [EST]
E-value 2e-11 prot=2924..2966 DNA=3274824..3274952 fr=3144 per=38/43 [EST]
E-value 9e-11 prot=1253..1292 DNA=3199010..3199132 fr=3144 per=40/41 [EST]
E-value 6e-21 prot=2616..2662 DNA=3267303..3267443 fr=3144 per=33/47 [EST]
CANDIDATE 3
DNA (Note) PROTEIN: [NP_003432] [NP_597731] [NP_710158] [NP_872330]

This candidate may be overlapping with a pseudogene (Note)
R-score = 0.011794; GO-score = 0.000164
0 bp Chromosome 4 13401795 bp
   
   
1 aa NP_033599 447 aa

Similarity found to protein:
[22771|NP_033599] | Mus musculus | zinc finger protein of the cerebellum 1 | length=447 aa
GO annotation:

0.000000 nucleic acid binding (function)
0.000003 DNA binding (function)
0.000003 nucleus (component)
0.000006 development (process)
0.000007 nervous system development (process)
0.000005 central nervous system development (process)
0.000164 behavior (process)
0.000003 zinc ion binding (function)
0.000014 cell differentiation (process)
0.000000 metal ion binding (function)
BLASTX hits:
E-value 2e-24 prot=240..384 DNA=357165..357560 fr=447 per=63/145 [EST] [P]
E-value 2e-21 prot=240..384 DNA=145414..145809 fr=447 per=56/145 [EST] [P]
E-value 9e-21 prot=242..384 DNA=427411..427022 fr=447 per=53/143 [EST] [P]
E-value 5e-20 prot=240..388 DNA=145246..145653 fr=447 per=57/149 [EST] [P]
E-value 5e-20 prot=240..384 DNA=255636..255241 fr=447 per=59/145 [EST] [P]
E-value 8e-20 prot=240..405 DNA=427501..427049 fr=447 per=61/168 [EST] [P]
E-value 1e-19 prot=240..386 DNA=357081..357482 fr=447 per=53/147 [EST] [P]
E-value 2e-19 prot=265..384 DNA=76483..76815 fr=447 per=54/120 [EST] [P]
E-value 2e-19 prot=240..384 DNA=426829..426434 fr=447 per=53/145 [EST] [P]
E-value 2e-19 prot=240..384 DNA=357249..357644 fr=447 per=58/145 [EST] [P]
E-value 2e-19 prot=240..384 DNA=426325..425930 fr=447 per=57/145 [EST] [P]
E-value 3e-19 prot=240..384 DNA=255888..255493 fr=447 per=54/145 [EST] [P]
E-value 7e-19 prot=242..384 DNA=426739..426350 fr=447 per=52/143 [EST] [P]
E-value 9e-19 prot=240..384 DNA=145498..145893 fr=447 per=57/145 [EST] [P]
E-value 9e-19 prot=240..382 DNA=76924..77313 fr=447 per=57/143 [EST] [P]
E-value 1e-18 prot=242..384 DNA=427915..427526 fr=447 per=56/143 [EST] [P]
E-value 1e-18 prot=240..440 DNA=76672..77250 fr=447 per=68/210 [EST] [P]
E-value 1e-18 prot=240..384 DNA=145162..145557 fr=447 per=56/145 [EST] [P]
E-value 1e-18 prot=240..384 DNA=255468..255073 fr=447 per=59/145 [EST] [P]
E-value 1e-18 prot=240..384 DNA=426157..425678 fr=447 per=57/164 [EST] [P]
E-value 4e-18 prot=240..408 DNA=427165..426704 fr=447 per=63/171 [EST] [P]
E-value 6e-18 prot=272..384 DNA=76060..76395 fr=447 per=47/116 [EST] [P]
E-value 7e-18 prot=274..384 DNA=238226..238537 fr=447 per=48/111 [EST] [P]
E-value 7e-18 prot=240..384 DNA=425905..425510 fr=447 per=53/145 [EST] [P]
E-value 1e-17 prot=240..410 DNA=76168..76713 fr=447 per=62/197 [EST] [P]
E-value 2e-17 prot=275..386 DNA=144988..145311 fr=447 per=46/112 [EST] [P]
E-value 2e-17 prot=240..384 DNA=76252..76731 fr=447 per=59/171 [EST] [P]
E-value 2e-17 prot=281..384 DNA=238157..238453 fr=447 per=47/104 [EST] [P]
E-value 2e-17 prot=240..384 DNA=427585..427190 fr=447 per=54/145 [EST] [P]
E-value 4e-17 prot=240..384 DNA=356745..357224 fr=447 per=54/164 [EST] [P]
E-value 5e-17 prot=240..384 DNA=256137..255745 fr=447 per=56/145 [EST] [P]
E-value 5e-17 prot=225..383 DNA=238181..238618 fr=447 per=55/159 [EST] [P]
E-value 6e-17 prot=240..384 DNA=427081..426686 fr=447 per=47/145 [EST] [P]
E-value 8e-17 prot=240..384 DNA=255384..254989 fr=447 per=55/145 [EST] [P]
E-value 2e-16 prot=242..383 DNA=426655..426269 fr=447 per=53/142 [EST] [P]
E-value 3e-16 prot=240..408 DNA=426241..425780 fr=447 per=63/171 [EST] [P]
E-value 2e-15 prot=240..384 DNA=255300..254905 fr=447 per=55/145 [EST] [P]
E-value 1e-14 prot=294..384 DNA=427618..427358 fr=447 per=37/91 [EST] [P]
E-value 3e-14 prot=293..388 DNA=254750..254475 fr=447 per=39/96 [EST] [P]
E-value 3e-12 prot=242..382 DNA=357339..357722 fr=447 per=48/141 [EST] [P]
E-value 1e-11 prot=240..384 DNA=255216..254821 fr=447 per=51/145 [EST] [P]
E-value 2e-11 prot=240..384 DNA=254714..254322 fr=447 per=44/145 [EST] [P]
E-value 7e-11 prot=240..382 DNA=254630..254244 fr=447 per=45/143 [EST] [P]
E-value 8e-11 prot=309..377 DNA=237899..238099 fr=447 per=30/69 [EST] [P]
E-value 8e-11 prot=276..302 DNA=237808..237888 fr=447 per=10/27 [EST] [P]
CANDIDATE 4
DNA (Note) PROTEIN: [NP_000133] [NP_075254]
R-score = 0.012657; GO-score = 0.000162
0 bp Chromosome 4 13401795 bp
   
   
1 aa NP_038718 1125 aa

Similarity found to protein:
[21687|NP_038718] | Mus musculus | endothelial-specific receptor tyrosine kinase | length=1125 aa
GO annotation:
0.000005 nucleotide binding (function)
0.000004 protein kinase activity (function)
0.000004 protein serine/threonine kinase activity (function)
0.000004 protein-tyrosine kinase activity (function)
0.000008 receptor activity (function)
0.000003 structural molecule activity (function)
0.000004 ATP binding (function)
0.000010 extracellular space (component)
0.000004 protein amino acid phosphorylation (process)
0.000011 cell-matrix adhesion (process)
0.000005 integral to membrane (component)
0.000002 kinase activity (function)
0.000000 cell-cell adhesion (process)
0.000003 transferase activity (function)
0.000162 regulation of cell migration (process)
0.000000 regulation of angiogenesis (process)
BLASTX hits:
E-value 2e-18 prot=962..1002 DNA=1774962..1775090 fr=1125 per=25/43 [EST]
E-value 2e-18 prot=899..960 DNA=1774663..1774848 fr=1125 per=22/62 [EST]
E-value 2e-18 prot=862..893 DNA=1774472..1774567 fr=1125 per=16/32 [EST]
E-value 2e-18 prot=997..1023 DNA=1775159..1775239 fr=1125 per=16/27 [EST]
E-value 2e-18 prot=831..856 DNA=1774282..1774353 fr=1125 per=12/26 [EST]
CANDIDATE 5
DNA (Note)
R-score = 0.023186; GO-score = 0.000093
0 bp Chromosome 4 13401795 bp
   
  
1 aa NP_059144 332 aa

Similarity found to protein:
[3948|NP_059144] | Homo sapiens | lactate dehydrogenase C | length=332 aa
GO annotation:
0.000093 L-lactate dehydrogenase activity (function)
0.000005 cytoplasm (component)
0.000000 tricarboxylic acid cycle intermediate metabolism (process)
0.000000 oxidoreductase activity (function)
0.000000 anaerobic glycolysis (process)
BLASTX hits:
E-value 1e-109 prot=129..268 DNA=5014590..5014174 fr=332 per=96/140 [EST]
E-value 1e-109 prot=1..135 DNA=5014973..5014569 fr=332 per=83/135 [EST]
E-value 1e-109 prot=271..323 DNA=5014168..5014010 fr=332 per=34/53 [EST]
CANDIDATE 6
DNA (Note)
R-score = 0.023244; GO-score = 0.000093
0 bp Chromosome 4 13401795 bp
   
  
1 aa NP_034829 332 aa

Similarity found to protein:
[16828|NP_034829] | Mus musculus | lactate dehydrogenase 1, A chain | length=332 aa
GO annotation:
0.000093 L-lactate dehydrogenase activity (function)
0.000005 cytoplasm (component)
0.000050 glycolysis (process)
0.000000 tricarboxylic acid cycle intermediate metabolism (process)
0.000000 oxidoreductase activity (function)
0.000000 anaerobic glycolysis (process)
BLASTX hits:
E-value 8e-80 prot=126..268 DNA=5014599..5014174 fr=332 per=116/143 [EST]
E-value 4e-50 prot=1..135 DNA=5014973..5014569 fr=332 per=111/135 [EST]
E-value 8e-80 prot=271..323 DNA=5014168..5014010 fr=332 per=47/53 [EST]
CANDIDATE 7
DNA (Note)
R-score = 0.023301; GO-score = 0.000093
0 bp Chromosome 4 13401795 bp
   
  
1 aa NP_005557 332 aa

Similarity found to protein:
[3939|NP_005557] | Homo sapiens | lactate dehydrogenase A | length=332 aa
GO annotation:
0.000093 L-lactate dehydrogenase activity (function)
0.000005 protein binding (function)
0.000006 cytosol (component)
0.000000 tricarboxylic acid cycle intermediate metabolism (process)
0.000000 oxidoreductase activity (function)
0.000000 anaerobic glycolysis (process)
BLASTX hits:
E-value 4e-83 prot=126..268 DNA=5014599..5014174 fr=332 per=120/143 [EST]
E-value 7e-53 prot=1..135 DNA=5014973..5014569 fr=332 per=114/135 [EST]
E-value 4e-83 prot=271..323 DNA=5014168..5014010 fr=332 per=48/53 [EST]
CANDIDATE 8
DNA (Note)
R-score = 0.023359; GO-score = 0.000093
0 bp Chromosome 4 13401795 bp
   
    
1 aa NP_002291 334 aa

Similarity found to protein:
[3945|NP_002291] | Homo sapiens | lactate dehydrogenase B | length=334 aa
GO annotation:
0.000093 L-lactate dehydrogenase activity (function)
0.000005 cytoplasm (component)
0.000000 tricarboxylic acid cycle intermediate metabolism (process)
0.000000 oxidoreductase activity (function)
0.000000 anaerobic glycolysis (process)
BLASTX hits:
E-value 1e-110 prot=127..265 DNA=5014599..5014183 fr=334 per=98/139 [EST]
E-value 1e-110 prot=1..130 DNA=5014973..5014587 fr=334 per=93/130 [EST]
E-value 1e-110 prot=272..326 DNA=5014168..5014004 fr=334 per=29/55 [EST]
CANDIDATE 9
DNA (Note)
R-score = 0.023416; GO-score = 0.000093
0 bp Chromosome 4 13401795 bp
   
  
1 aa NP_058721 332 aa

Similarity found to protein:
[24533|NP_058721] | Rattus norvegicus | lactate dehydrogenase A | length=332 aa
GO annotation:
0.000000 lactate dehydrogenase activity (function)
0.000093 L-lactate dehydrogenase activity (function)
0.000006 cytosol (component)
0.000050 glycolysis (process)
0.000000 tricarboxylic acid cycle intermediate metabolism (process)
0.000000 oxidoreductase activity (function)
BLASTX hits:
E-value 3e-80 prot=126..268 DNA=5014599..5014174 fr=332 per=116/143 [EST]
E-value 2e-50 prot=1..135 DNA=5014973..5014569 fr=332 per=111/135 [EST]
E-value 3e-80 prot=271..323 DNA=5014168..5014010 fr=332 per=47/53 [EST]
CANDIDATE 10
DNA (Note)
R-score = 0.023474; GO-score = 0.000093
0 bp Chromosome 4 13401795 bp
   
    
1 aa NP_038608 332 aa

Similarity found to protein:
[16833|NP_038608] | Mus musculus | lactate dehydrogenase 3, C chain, sperm specific | length=332 aa
GO annotation:
0.000004 catalytic activity (function)
0.000093 L-lactate dehydrogenase activity (function)
0.000005 cytoplasm (component)
0.000050 glycolysis (process)
0.000000 tricarboxylic acid cycle intermediate metabolism (process)
0.000000 oxidoreductase activity (function)
0.000000 anaerobic glycolysis (process)
BLASTX hits:
E-value 1e-103 prot=129..264 DNA=5014590..5014183 fr=332 per=94/136 [EST]
E-value 1e-103 prot=1..135 DNA=5014973..5014569 fr=332 per=77/135 [EST]
E-value 1e-103 prot=271..323 DNA=5014168..5014010 fr=332 per=33/53 [EST]