Analysis of Asthma chr5
Analysis of Asthma chr5 G2D Home
GO TO:
REASONS FOR ASSOCIATION OVERVIEW OF CANDIDATES BEST 10 CANDIDATES BEST 100 CANDIDATES

CHROMOSOMAL REGION
Disease mapped: Asthma chr5
Method: Md
Chromosome: 5
Genomic position start-stop: 137121818-151121818
length: 14000001
Band: q31.2-q33.1
 LINKS

EntrezGene: no link

MEDLINE:

OMIM: no link

REASONS FOR ASSOCIATION

MEDLINE QUERY
A set of 4317 papers related to asthma was derived from MEDLINE using the query:
Asthma [MH] AND Case Report [MH]

MESH-C TERMS
The MeSH-C terms associated to the derived papers were collected and manually filtered.

Here you can see the terms ordered by the fraction of papers where they were found.

Asthma [0.957365269461078]
Status Asthmaticus [0.0548502994011976]
Drug Hypersensitivity [0.0431137724550898]
Bronchial Spasm [0.0304191616766467]
Eosinophilia [0.0297005988023952]
Bronchitis [0.0239520958083832]
Airway Obstruction [0.0239520958083832]
Rhinitis [0.0208383233532934]
Food Hypersensitivity [0.0205988023952096]
Anaphylaxis [0.0203592814371257]
We show here only the 10 most frequent. You can also see the complete list of 50 MeSH-C terms.

Each name is linked to the corresponding term description by the NLM. The number in brackets is linked to the list of papers that contained the term. The points to the related MeSH-D terms.

 GO terms
We computed the GO terms associated to the MeSH-C terms selected for this disease.

Here you can see those with higher score of association.

0.000797 peptidyl-dipeptidase activity (function)
0.000404 interleukin-5 receptor activity (function)
0.000356 fluid secretion (process)
0.000291 peroxidase activity (function)
0.000283 protein kinase inhibitor activity (function)
0.000261 pancreatic elastase activity (function)
0.000233 leukotriene-C4 synthase activity (function)
0.000230 renin activity (function)
0.000230 cathepsin D activity (function)
0.000228 angiotensin type II receptor activity (function)
We show here only the top 10. You can also see the complete list of 2490 GO terms.

Each name is linked to the corresponding term description by GO. The number indicates the strength of association to Asthma chr5. The points to the related MeSH-D terms.
Follow the green arrows to navigate MeSH-C / MeSH-D / GO-terms relationship derived from our analysis of the whole MEDLINE database, and used to relate the phenotype of this disease to terms of gene functionality.

OVERVIEW OF CANDIDATES IN THE REGION

The graph represents the BLASTX hits found in the region and the genes predicted or known in the region.

Legend:
BLASTX hits RefSeq genes Ensembl genes
                                                                                                                                                     
> 1e-10 > 1e-20 > 1e-50 > 1e-80 > 1e-100 > 0
                           
                               

Graph with GO scoring vs genomic position [PostScript graphic]

BEST SCORING 10 CANDIDATES
Here we show only the best scoring ten candidates but there are more. You can see the best scoring 100 candidates.

What is in a candidate?

CANDIDATE 1
DNA (Note)
R-score = 0.000805; GO-score = 0.000356
137121818 bp Chromosome 5 151121818 bp
   
   
1 aa NP_114438 359 aa

Similarity found to protein:
[185|NP_114438] | Homo sapiens | angiotensin II receptor, type 1 | length=359 aa
GO annotation:
0.000000 rhodopsin-like receptor activity (function)
0.000008 receptor activity (function)
0.000228 angiotensin type II receptor activity (function)
0.000108 bradykinin receptor activity (function)
0.000020 plasma membrane (component)
0.000015 integral to plasma membrane (component)
0.000017 signal transduction (process)
0.000032 G-protein coupled receptor protein signaling pathway (process)
0.000104 G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) (process)
0.000061 elevation of cytosolic calcium ion concentration (process)
0.000356 fluid secretion (process)
0.000043 circulation (process)
0.000005 integral to membrane (component)
0.000000 C-X-C chemokine receptor activity (function)
BLASTX hits:
E-value 9e-13 prot=36..234 DNA=148179308..148179904 fr=359 per=59/207 [EST]
CANDIDATE 2
DNA (Note)
R-score = 0.001093; GO-score = 0.000291
137121818 bp Chromosome 5 151121818 bp
   
  
1 aa NP_523891 1527 aa

Similarity found to protein:
[38326|NP_523891] | Drosophila melanogaster | Peroxidasin CG12002-PB | length=1527 aa
GO annotation:
0.000291 peroxidase activity (function)
0.000021 extracellular matrix (sensu Metazoa) (component)
0.000008 oxygen and reactive oxygen species metabolism (process)
0.000018 defense response (process)
BLASTX hits:
E-value 8e-12 prot=1..184 DNA=138231191..138230670 fr=1527 per=56/185 [EST]
CANDIDATE 3
DNA (Note)
R-score = 0.005811; GO-score = 0.000228
137121818 bp Chromosome 5 151121818 bp
   
       
1 aa NP_034046 360 aa

Similarity found to protein:
[12773|NP_034046] | Mus musculus | chemokine (C-C motif) receptor 4 | length=360 aa
GO annotation:
0.000000 rhodopsin-like receptor activity (function)
0.000012 signal transducer activity (function)
0.000008 receptor activity (function)
0.000013 G-protein coupled receptor activity (function)
0.000228 angiotensin type II receptor activity (function)
0.000045 chemotaxis (process)
0.000038 inflammatory response (process)
0.000017 signal transduction (process)
0.000032 G-protein coupled receptor protein signaling pathway (process)
0.000005 integral to membrane (component)
0.000101 C-C chemokine receptor activity (function)
BLASTX hits:
E-value 1e-11 prot=77..189 DNA=147204858..147204523 fr=360 per=33/113 [EST]
E-value 1e-11 prot=210..311 DNA=147204421..147204122 fr=360 per=28/102 [EST]
E-value 1e-11 prot=32..64 DNA=147204994..147204896 fr=360 per=12/33 [EST]
CANDIDATE 4
DNA (Note)
R-score = 0.006099; GO-score = 0.000228
137121818 bp Chromosome 5 151121818 bp
   
   
1 aa NP_112247 359 aa

Similarity found to protein:
[24180|NP_112247] | Rattus norvegicus | angiotensin receptor 1a | length=359 aa
GO annotation:
0.000000 rhodopsin-like receptor activity (function)
0.000000 angiotensin type I receptor activity (function)
0.000000 ureteric bud branching (process)
0.000008 receptor activity (function)
0.000013 G-protein coupled receptor activity (function)
0.000228 angiotensin type II receptor activity (function)
0.000016 endosome (component)
0.000020 plasma membrane (component)
0.000030 regulation of pH (process)
0.000032 G-protein coupled receptor protein signaling pathway (process)
0.000104 G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) (process)
0.000008 excretion (process)
0.000207 blood pressure regulation (process)
0.000005 integral to membrane (component)
BLASTX hits:
E-value 9e-13 prot=36..234 DNA=148179308..148179904 fr=359 per=61/211 [EST]
CANDIDATE 5
DNA (Note)
R-score = 0.006329; GO-score = 0.000207
137121818 bp Chromosome 5 151121818 bp
     
  
1 aa NP_036624 418 aa

Similarity found to protein:
[24176|NP_036624] | Rattus norvegicus | adrenergic receptor, beta 2 | length=418 aa
GO annotation:
0.000024 activation of MAPK activity (process)
0.000000 rhodopsin-like receptor activity (function)
0.000008 receptor activity (function)
0.000013 G-protein coupled receptor activity (function)
0.000000 adrenoceptor activity (function)
0.000058 beta-adrenergic receptor activity (function)
0.000048 beta2-adrenergic receptor activity (function)
0.000017 lysosome (component)
0.000016 endosome (component)
0.000015 integral to plasma membrane (component)
0.000015 receptor mediated endocytosis (process)
0.000044 transmembrane receptor protein tyrosine kinase activation (dimerization) (process)
0.000032 G-protein coupled receptor protein signaling pathway (process)
0.000027 G-protein signaling, coupled to cAMP nucleotide second messenger (process)
0.000020 adenylate cyclase activation (process)
0.000022 protein kinase cascade (process)
0.000037 respiratory gaseous exchange (process)
0.000207 blood pressure regulation (process)
0.000040 endosome to lysosome transport (process)
0.000005 integral to membrane (component)
0.000000 apical plasma membrane (component)
BLASTX hits:
E-value 8e-22 prot=179..341 DNA=147862424..147861954 fr=418 per=61/164 [EST]
E-value 0.0 prot=5..418 DNA=148179200..148180426 fr=418 per=356/414 [EST]
CANDIDATE 6
DNA (Note)

This candidate may be overlapping with a pseudogene (Note)
R-score = 0.006559; GO-score = 0.000207
137121818 bp Chromosome 5 151121818 bp
   
   
1 aa NP_001718 399 aa

Similarity found to protein:
[680|NP_001718] | Homo sapiens | bombesin-like receptor 3 | length=399 aa
GO annotation:

0.000000 rhodopsin-like receptor activity (function)
0.000008 receptor activity (function)
0.000030 bombesin receptor activity (function)
0.000020 plasma membrane (component)
0.000020 glucose metabolism (process)
0.000022 smooth muscle contraction (process)
0.000017 signal transduction (process)
0.000032 G-protein coupled receptor protein signaling pathway (process)
0.000023 response to nutrient (process)
0.000207 blood pressure regulation (process)
0.000008 adult feeding behavior (process)
0.000005 integral to membrane (component)
BLASTX hits:
E-value 2e-15 prot=41..286 DNA=137165042..137165776 fr=399 per=69/256 [EST] [P]
E-value 2e-15 prot=305..365 DNA=137165824..137166006 fr=399 per=14/61 [EST] [P]
E-value 2e-17 prot=52..349 DNA=148179299..148180216 fr=399 per=82/319 [EST] [P]
CANDIDATE 7
DNA (Note)

This candidate may be overlapping with a pseudogene (Note)
R-score = 0.007019; GO-score = 0.000207
137121818 bp Chromosome 5 151121818 bp
   
   
1 aa NP_035064 382 aa

Similarity found to protein:
[18166|NP_035064] | Mus musculus | neuropeptide Y receptor Y1 | length=382 aa
GO annotation:

0.000000 rhodopsin-like receptor activity (function)
0.000000 peptide YY receptor activity (function)
0.000000 pancreatic polypeptide receptor activity (function)
0.000012 signal transducer activity (function)
0.000008 receptor activity (function)
0.000013 G-protein coupled receptor activity (function)
0.000019 neuropeptide Y receptor activity (function)
0.000020 glucose metabolism (process)
0.000017 signal transduction (process)
0.000032 G-protein coupled receptor protein signaling pathway (process)
0.000006 neuropeptide signaling pathway (process)
0.000042 locomotory behavior (process)
0.000026 feeding behavior (process)
0.000207 blood pressure regulation (process)
0.000005 integral to membrane (component)
0.000127 sensory perception of pain (process)
0.000076 regulation of body size (process)
BLASTX hits:
E-value 3e-84 prot=27..277 DNA=137165015..137165776 fr=382 per=139/254 [EST] [P]
E-value 3e-84 prot=280..366 DNA=137165782..137166039 fr=382 per=48/87 [EST] [P]
E-value 4e-15 prot=42..319 DNA=148179293..148180165 fr=382 per=67/303 [EST] [P]
CANDIDATE 8
DNA (Note) PROTEIN: [NP_006687] (Itself) [NP_631938] [NP_899203]
R-score = 0.009723; GO-score = 0.000184
137121818 bp Chromosome 5 151121818 bp
   
           
1 aa NP_006687 920 aa

Similarity found to protein:
[10902|NP_006687] | Homo sapiens | bromodomain containing 8 isoform 3 | length=920 aa
GO annotation:
0.000002 regulation of cell growth (process)
0.000004 transcription factor activity (function)
0.000184 ligand-regulated transcription factor activity (function)
0.000009 transcription coactivator activity (function)
0.000016 thyroid hormone receptor activity (function)
0.000003 nucleus (component)
0.000007 transcription (process)
0.000005 regulation of transcription from RNA polymerase II promoter (process)
0.000023 cell surface receptor linked signal transduction (process)
0.000000 chromatin modification (process)
BLASTX hits:
E-value 5e-74 prot=451..619 DNA=137521958..137521452 fr=920 per=155/169 [EST]
E-value 7e-45 prot=375..469 DNA=137522847..137522563 fr=920 per=95/95 [EST]
E-value 2e-32 prot=666..737 DNA=137520085..137519870 fr=920 per=72/72 [EST]
E-value 8e-25 prot=792..851 DNA=137517808..137517629 fr=920 per=60/60 [EST]
E-value 7e-21 prot=185..257 DNA=137525423..137525205 fr=920 per=73/73 [EST]
E-value 7e-18 prot=257..305 DNA=137524816..137524670 fr=920 per=49/49 [EST]
E-value 9e-18 prot=138..185 DNA=137526097..137525954 fr=920 per=47/48 [EST]
E-value 3e-16 prot=792..855 DNA=137497622..137497431 fr=920 per=43/64 [EST]
E-value 2e-25 prot=48..91 DNA=137527900..137527769 fr=920 per=42/44 [EST]
E-value 2e-25 prot=88..116 DNA=137527655..137527569 fr=920 per=29/29 [EST]
CANDIDATE 9
DNA (Note)
R-score = 0.010241; GO-score = 0.000164
137121818 bp Chromosome 5 151121818 bp
   
   
1 aa NP_001832 360 aa

Similarity found to protein:
[1269|NP_001832] | Homo sapiens | cannabinoid receptor 2 (macrophage) | length=360 aa
GO annotation:
0.000008 receptor activity (function)
0.000009 cannabinoid receptor activity (function)
0.000020 plasma membrane (component)
0.000015 integral to plasma membrane (component)
0.000018 immune response (process)
0.000017 signal transduction (process)
0.000015 G-protein signaling, coupled to cyclic nucleotide second messenger (process)
0.000164 behavior (process)
BLASTX hits:
E-value 2e-12 prot=36..307 DNA=148179293..148180186 fr=360 per=80/307 [EST]
CANDIDATE 10
DNA (Note)

This candidate may be overlapping with a pseudogene (Note)
R-score = 0.010471; GO-score = 0.000164
137121818 bp Chromosome 5 151121818 bp
     
   
1 aa NP_037203 398 aa

Similarity found to protein:
[25601|NP_037203] | Rattus norvegicus | opioid receptor, mu 1 | length=398 aa
GO annotation:

0.000000 rhodopsin-like receptor activity (function)
0.000008 receptor activity (function)
0.000013 G-protein coupled receptor activity (function)
0.000019 neuropeptide Y receptor activity (function)
0.000005 opioid receptor activity (function)
0.000024 mu-opioid receptor activity (function)
0.000006 membrane fraction (component)
0.000005 endoplasmic reticulum (component)
0.000002 Golgi apparatus (component)
0.000015 integral to plasma membrane (component)
0.000018 immune response (process)
0.000032 G-protein coupled receptor protein signaling pathway (process)
0.000015 G-protein signaling, coupled to cyclic nucleotide second messenger (process)
0.000012 dopamine receptor, adenylate cyclase activating pathway (process)
0.000007 G-protein signaling, adenylate cyclase inhibiting pathway (process)
0.000019 sensory perception (process)
0.000164 behavior (process)
0.000005 negative regulation of cell proliferation (process)
0.000005 integral to membrane (component)
0.000000 purinergic nucleotide receptor activity, G-protein coupled (function)
BLASTX hits:
E-value 1e-12 prot=210..343 DNA=147204529..147204122 fr=398 per=38/154 [EST] [P]
E-value 1e-12 prot=106..209 DNA=147204858..147204553 fr=398 per=27/104 [EST] [P]
E-value 1e-22 prot=76..356 DNA=148179308..148180225 fr=398 per=84/312 [EST] [P]