Welcome to the G2D web server (version 4.1). Here you can use our algorithms to scan a human genomic region for genes related to an inherited disease. From the links under G2D datasets, on the left, you can also access a database of pre-computed results for mapped monogenic human diseases and for asthma, a complex disease.

Candidate priorities are automatically established by data mining algorithms that extract putative genes in the chromosomal region where the disease is mapped, and evaluate their possible relation to the disease based on the phenotype of the disorder or their similarity to an already known related gene. If the phenotype have been linked to more than one locus, known or inferred interactions between proteins from two loci can be also examined. To know more about g2d.

PHENOTYPE

KNOWN GENES

INTERACTIONS

PHENOTYPE BOX Type one MIM number defining the disease picked from this list (e.g. 131244)

LOCATION BOX Type a location and select format and chromosome (maximum 50 Mb) format: Select Band(s) Marker(s) Positions chromosome: Select 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y Band(s) e.g. q13.2 Marker(s) e.g. D9S201 D9S298 Positions e.g. 63950000 73950000

OUTPUT BOX For quicker results limit the number of results in your output. Homology to candidates under E-value (Min 1e-10). Show only the best candidates (Maximum 100). Organize the candidates by RefSeq genes collapsed verbose none